Q6H1D0 · Q6H1D0_9ADEN

  • Protein
    Pre-hexon-linking protein IIIa
  • Gene
    L1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

159150100150200250300350400450500550
TypeIDPosition(s)Description
Site576-577Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid, decoration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-hexon-linking protein IIIa
  • Alternative names
    • Capsid vertex-specific component IIIa
      (CVSC
      )
    • Protein IIIa
    • pIIIa
  • Cleaved into 1 chains

Gene names

    • Name
      L1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Vaccine
    • HAdV-E/USA/4054/2015/P4H4F4
  • Taxonomic lineage
    Viruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus

Accessions

  • Primary accession
    Q6H1D0

Proteomes

Subcellular Location

Virion
Host nucleus
Note: Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, propeptide.

TypeIDPosition(s)Description
ChainPRO_50410244161-576Hexon-linking protein IIIa
ChainPRO_50410244181-591Pre-hexon-linking protein IIIa
Modified residue226Phosphoserine; by host
Modified residue275Phosphothreonine; by host
Modified residue447Phosphoserine; by host
Modified residue465Phosphoserine; by host
Modified residue473Phosphoserine; by host
Modified residue490Phosphotyrosine; by host
Modified residue494Phosphoserine; by host
Modified residue511Phosphoserine; by host
PropeptidePRO_5041024417577-591

Post-translational modification

Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-25Disordered
Region1-107Peripentonal hexon-tethering domain
Region139-252Binding to hexon-linking protein
Region423-458Disordered
Region524-591Disordered

Sequence similarities

Belongs to the adenoviridae hexon-linking protein IIIa family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    591
  • Mass (Da)
    65,900
  • Last updated
    2004-07-19 v1
  • Checksum
    1E01EC4F7F98F8F5
MQQQPPPDPAMRAALQSQPSGINSSDDWTQAMQRIMALTTRNPEAFRQQPQANRLSAILEAVVPSRSNPTHEKVLAIVNALVENKAIRGDEAGLVYNALLERVARYNSTNVQTNLDRMVTDVREAVAQRERFHRESNLGSMVALNAFLSTQPANVPRGQEDYTNFISALRLMVTEVPQSEVYQSGPDYFFQTSRQGLQTVNLSQAFKNLQGLWGVQAPVGDRATVSSLLTPNSRLLLLLVAPFTDSGSINRNSYLGYLINLYREAIGQAHVDEQTYQEITHVSRALGQDDPGNLEATLNFLLTNRSQKIPPQYALSAEEERILRYVQQSVGLFLMQEGATPSAALDMTARNMEPSMYASNRPFINKLMDYLHRAAAMNSDYFTNAILNPHWLPPPGFYTGEYDMPDPNDGFLWDDVDSSVFSPRPGANERPLWKKEGSDRRPSSALSGRTGAAAAVPEAASPFPSLSLNSVRSSELGRITRPRLLGEEEYLNNSLLRPEREKNFPNNGIESLVDKMSRWKTYAHEHRDDPRATQGATSRGSAARKRRWHDRQRGLMWDDEDSADDSSVLDLGGSGGGNPFAHLRPRVGRLM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY487947
EMBL· GenBank· DDBJ
AAS66919.1
EMBL· GenBank· DDBJ
Genomic DNA
KY996447
EMBL· GenBank· DDBJ
AVQ69366.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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