Q6GX86 · HROB_RAT

  • Protein
    Homologous recombination OB-fold protein
  • Gene
    Hrob
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componentsite of DNA damage
Molecular Functionsingle-stranded DNA binding
Biological ProcessDNA damage response
Biological ProcessDNA synthesis involved in DNA repair
Biological Processfemale gamete generation
Biological Processinterstrand cross-link repair
Biological Processmale gamete generation
Biological Processrecombinational repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homologous recombination OB-fold protein

Gene names

    • Name
      Hrob

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q6GX86
  • Secondary accessions
    • Q6GX87

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Chromosome
Note: Localized to the sites of DNA damage.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002880941-607Homologous recombination OB-fold protein
Modified residue30Phosphoserine
Modified residue281Asymmetric dimethylarginine

Keywords

Proteomic databases

PTM databases

Expression

Induction

By E2F1 and serum stimulation.

Gene expression databases

Interaction

Subunit

Interacts with MCM8; this interaction is necessary for MCM8-MCM9 helicase complex recruitment to DNA damage sites (By similarity).
Interacts with RPA1; this interaction associates HROB with the RPA complex (By similarity).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region25-49Disordered
Compositional bias28-49Polar residues
Region84-108Disordered
Region196-308Disordered
Compositional bias208-227Polar residues
Compositional bias235-281Polar residues
Compositional bias288-308Polar residues
Region531-581Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    65,159
  • Last updated
    2004-07-19 v1
  • Checksum
    B6BA80E9B9989B3E
MDFLSALENAENHIVSALPGDAVCLRPNSSRPQETPQAHSSKLSPSYPASNRSVLGLCFPTSRMPETIKEPPCKGAMFLRPVSISSSSSGSQQRMTGTKVSQESSGRQSSAAHSGFIFESCQHGIGDFETLDQDEFDKALASMEFEGAGLEPEVNRGASQILPAKHCEDPVLAKKARVADLSGSFQEGPIVHCRKPWPSLRPTTATGGLPVPATSDISTSHQRGSPVPAPQYSPVAGRTLQNGPQNYVPGQPLQSPRAWSSGKPRFSGPQCPHSSSAAFCRGPSPSRAPVSSVESPFSTPRSTSTTVTQPALQTPVVTNHLVQLVTATNRTPQQPSRPSIRAKTRRFPGPAGLLPHQHSGENLEEIMVSTPQTPTHGALAKFQTEIVTSSQGSVEEDFGRGPWLTMKSALGLDEGDPTCFLYTYSIVMVLRKAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMLGTVHRVLLETHQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSLDSGDGDFLKPPQPLPKDLGNSHGSLQPDVAAEPTQGLRTAQNPPASPEEELPEADDLDGLLSELPEDFFCEPSGWSCLKTGHPP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2K9P1A0A0G2K9P1_RATHrob624
A0A8I6A3H9A0A8I6A3H9_RATHrob590

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias28-49Polar residues
Compositional bias208-227Polar residues
Compositional bias235-281Polar residues
Compositional bias288-308Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY623029
EMBL· GenBank· DDBJ
AAT46046.1
EMBL· GenBank· DDBJ
mRNA
AY623030
EMBL· GenBank· DDBJ
AAT46047.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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