Q6GX86 · HROB_RAT
- ProteinHomologous recombination OB-fold protein
- GeneHrob
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids607 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | site of DNA damage | |
Molecular Function | single-stranded DNA binding | |
Biological Process | DNA damage response | |
Biological Process | DNA synthesis involved in DNA repair | |
Biological Process | female gamete generation | |
Biological Process | interstrand cross-link repair | |
Biological Process | male gamete generation | |
Biological Process | recombinational repair |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHomologous recombination OB-fold protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ6GX86
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localized to the sites of DNA damage.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000288094 | 1-607 | Homologous recombination OB-fold protein | |||
Sequence: MDFLSALENAENHIVSALPGDAVCLRPNSSRPQETPQAHSSKLSPSYPASNRSVLGLCFPTSRMPETIKEPPCKGAMFLRPVSISSSSSGSQQRMTGTKVSQESSGRQSSAAHSGFIFESCQHGIGDFETLDQDEFDKALASMEFEGAGLEPEVNRGASQILPAKHCEDPVLAKKARVADLSGSFQEGPIVHCRKPWPSLRPTTATGGLPVPATSDISTSHQRGSPVPAPQYSPVAGRTLQNGPQNYVPGQPLQSPRAWSSGKPRFSGPQCPHSSSAAFCRGPSPSRAPVSSVESPFSTPRSTSTTVTQPALQTPVVTNHLVQLVTATNRTPQQPSRPSIRAKTRRFPGPAGLLPHQHSGENLEEIMVSTPQTPTHGALAKFQTEIVTSSQGSVEEDFGRGPWLTMKSALGLDEGDPTCFLYTYSIVMVLRKAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMLGTVHRVLLETHQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSLDSGDGDFLKPPQPLPKDLGNSHGSLQPDVAAEPTQGLRTAQNPPASPEEELPEADDLDGLLSELPEDFFCEPSGWSCLKTGHPP | ||||||
Modified residue | 30 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 281 | Asymmetric dimethylarginine | ||||
Sequence: R |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with MCM8; this interaction is necessary for MCM8-MCM9 helicase complex recruitment to DNA damage sites (By similarity).
Interacts with RPA1; this interaction associates HROB with the RPA complex (By similarity).
Interacts with RPA1; this interaction associates HROB with the RPA complex (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-49 | Disordered | ||||
Sequence: LRPNSSRPQETPQAHSSKLSPSYPA | ||||||
Compositional bias | 28-49 | Polar residues | ||||
Sequence: NSSRPQETPQAHSSKLSPSYPA | ||||||
Region | 84-108 | Disordered | ||||
Sequence: ISSSSSGSQQRMTGTKVSQESSGRQ | ||||||
Region | 196-308 | Disordered | ||||
Sequence: PWPSLRPTTATGGLPVPATSDISTSHQRGSPVPAPQYSPVAGRTLQNGPQNYVPGQPLQSPRAWSSGKPRFSGPQCPHSSSAAFCRGPSPSRAPVSSVESPFSTPRSTSTTVT | ||||||
Compositional bias | 208-227 | Polar residues | ||||
Sequence: GLPVPATSDISTSHQRGSPV | ||||||
Compositional bias | 235-281 | Polar residues | ||||
Sequence: VAGRTLQNGPQNYVPGQPLQSPRAWSSGKPRFSGPQCPHSSSAAFCR | ||||||
Compositional bias | 288-308 | Polar residues | ||||
Sequence: APVSSVESPFSTPRSTSTTVT | ||||||
Region | 531-581 | Disordered | ||||
Sequence: LKPPQPLPKDLGNSHGSLQPDVAAEPTQGLRTAQNPPASPEEELPEADDLD |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)65,159
- Last updated2004-07-19 v1
- ChecksumB6BA80E9B9989B3E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0G2K9P1 | A0A0G2K9P1_RAT | Hrob | 624 | ||
A0A8I6A3H9 | A0A8I6A3H9_RAT | Hrob | 590 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 28-49 | Polar residues | ||||
Sequence: NSSRPQETPQAHSSKLSPSYPA | ||||||
Compositional bias | 208-227 | Polar residues | ||||
Sequence: GLPVPATSDISTSHQRGSPV | ||||||
Compositional bias | 235-281 | Polar residues | ||||
Sequence: VAGRTLQNGPQNYVPGQPLQSPRAWSSGKPRFSGPQCPHSSSAAFCR | ||||||
Compositional bias | 288-308 | Polar residues | ||||
Sequence: APVSSVESPFSTPRSTSTTVT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY623029 EMBL· GenBank· DDBJ | AAT46046.1 EMBL· GenBank· DDBJ | mRNA | ||
AY623030 EMBL· GenBank· DDBJ | AAT46047.1 EMBL· GenBank· DDBJ | mRNA |