that a mechanism by which Hippo pathway and F-actin synergize to modulate YAP activation and localization in the context of intervertebral disc degeneration and help to control nucleus pulposus cells proliferation
After 6 hours of antiorthostatic suspension alpha-actinin 1 and alpha-actinin 4 levels decreased in the membranous fraction of proteins of cardiomyocytes and soleus muscle fibers.
Alpha-Actinin mediates the formation of the template and organization of adhesions associated with actin filaments suggesting that actin crosslinking has a major role in this process.
Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue and show intracellular translocation of beta-catenin alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients.
PINCH1 Ilk and actinin from a complex to costameres in neonatal rat ventricular myocytes. This complex is stimulated by fibronectins and phenylephrine and by both by drug synergism to regulate cardiac myocyte hypertrophy.
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