Q6FRV2 · GSHR_CANGA
- ProteinGlutathione reductase
- GeneGLR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids476 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Maintains high levels of reduced glutathione in the cytosol.
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46-54 | FAD (UniProtKB | ChEBI) | |||
Active site | 465 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | fungal biofilm matrix | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | peroxisome | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | glutathione-disulfide reductase (NADPH) activity | |
Molecular Function | NADP binding | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione reductase
- EC number
- Short namesGR; GRase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Nakaseomyces
Accessions
- Primary accessionQ6FRV2
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000067966 | 1-476 | Glutathione reductase | ||
Disulfide bond | 54↔59 | Redox-active | |||
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)52,499
- Last updated2004-07-19 v1
- MD5 Checksum8EE18D47B36EB95F83E54A467CC01A89
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR380954 EMBL· GenBank· DDBJ | CAG59975.1 EMBL· GenBank· DDBJ | Genomic DNA |