Q6FR76 · UBC2_CANGA

Function

function

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.

Catalytic activity

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
    EC:2.3.2.23 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site88Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentcytoplasm
Cellular ComponentHULC complex
Cellular ComponentMUB1-RAD6-UBR2 ubiquitin ligase complex
Cellular Componentnucleus
Cellular ComponentRad6-Rad18 complex
Cellular ComponentRAD6-UBR2 ubiquitin ligase complex
Cellular ComponentUBR1-RAD6 ubiquitin ligase complex
Molecular FunctionATP binding
Molecular Functionproteasome binding
Molecular Functionsingle-stranded DNA binding
Molecular Functionsingle-stranded DNA helicase activity
Molecular Functionubiquitin conjugating enzyme activity
Biological Processcellular response to unfolded protein
Biological Processcytoplasm protein quality control by the ubiquitin-proteasome system
Biological ProcessDNA-templated transcription termination
Biological Processdouble-strand break repair via homologous recombination
Biological ProcessERAD pathway
Biological Processerror-free postreplication DNA repair
Biological Processerror-free translesion synthesis
Biological Processerror-prone translesion synthesis
Biological Processmeiotic DNA double-strand break formation
Biological Processmitotic G1 DNA damage checkpoint signaling
Biological Processnegative regulation of SREBP signaling pathway
Biological Processprotein polyubiquitination
Biological Processregulation of dipeptide transport
Biological Processsno(s)RNA transcription
Biological Processsporulation resulting in formation of a cellular spore
Biological Processstress-induced homeostatically regulated protein degradation pathway
Biological Processsubtelomeric heterochromatin formation
Biological Processtelomere maintenance via recombination
Biological Processtranscription by RNA polymerase II
Biological Processubiquitin-dependent protein catabolic process via the N-end rule pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-conjugating enzyme E2 2
  • EC number
  • Alternative names
    • E2 ubiquitin-conjugating enzyme 2
    • Ubiquitin carrier protein UBC2
    • Ubiquitin-protein ligase UBC2

Gene names

    • Name
      UBC2
    • Ordered locus names
      CAGL0I00352g

Organism names

Accessions

  • Primary accession
    Q6FR76

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000825291-167Ubiquitin-conjugating enzyme E2 2

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain4-150UBC core
Region148-167Disordered
Compositional bias150-167Acidic residues

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    19,189
  • Last updated
    2004-07-19 v1
  • Checksum
    A9EF7E08327079AE
MSTPARRRLMRDFKRMKEDSPPGVSASPLPDNVMVWNAMIIGPADTPYEDGTFRLLLEFDEDYPNKPPHVKFLSEMFHPNVYANGEICLDILQNRWTPTYDVASILTSIQSLFNDPNPASPANVEAATLFKDHKSQYIKRVKETVEKSWEDNMDDMDDSDEDDEDDE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias150-167Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR380955
EMBL· GenBank· DDBJ
CAG60205.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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