Q6FI23 · Q6FI23_HUMAN

  • Protein
    mitogen-activated protein kinase kinase
  • Gene
    MAP2K3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site93ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionMAP kinase kinase activity
Molecular Functionprotein kinase binding
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein tyrosine kinase activity
Biological Processcardiac muscle contraction
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to sorbitol
Biological Processheart development
Biological Processinflammatory response
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of nitric-oxide synthase biosynthetic process
Biological Processpositive regulation of protein phosphorylation
Biological Processregulation of cytokine production
Biological Processresponse to ischemia

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    mitogen-activated protein kinase kinase
  • EC number

Gene names

    • Name
      MAP2K3

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6FI23

Organism-specific databases

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues
Region1-46Disordered
Domain64-325Protein kinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    39,318
  • Last updated
    2005-05-10 v1
  • Checksum
    A80BA4FDFF8F75A2
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK315505
EMBL· GenBank· DDBJ
BAG37889.1
EMBL· GenBank· DDBJ
mRNA
AB451226
EMBL· GenBank· DDBJ
BAG70040.1
EMBL· GenBank· DDBJ
mRNA
AB451349
EMBL· GenBank· DDBJ
BAG70163.1
EMBL· GenBank· DDBJ
mRNA
CR536514
EMBL· GenBank· DDBJ
CAG38752.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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