Q6FI23 · Q6FI23_HUMAN
- Proteinmitogen-activated protein kinase kinase
- GeneMAP2K3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids347 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase activity | |
Molecular Function | protein kinase binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein tyrosine kinase activity | |
Biological Process | cardiac muscle contraction | |
Biological Process | cellular response to lipopolysaccharide | |
Biological Process | cellular response to sorbitol | |
Biological Process | heart development | |
Biological Process | inflammatory response | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | positive regulation of nitric-oxide synthase biosynthetic process | |
Biological Process | positive regulation of protein phosphorylation | |
Biological Process | regulation of cytokine production | |
Biological Process | response to ischemia |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemitogen-activated protein kinase kinase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6FI23
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | ||||
Sequence: MESPASSQPASMPQS | ||||||
Region | 1-46 | Disordered | ||||
Sequence: MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDS | ||||||
Domain | 64-325 | Protein kinase | ||||
Sequence: LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFF |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)39,318
- Last updated2005-05-10 v1
- ChecksumA80BA4FDFF8F75A2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | ||||
Sequence: MESPASSQPASMPQS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK315505 EMBL· GenBank· DDBJ | BAG37889.1 EMBL· GenBank· DDBJ | mRNA | ||
AB451226 EMBL· GenBank· DDBJ | BAG70040.1 EMBL· GenBank· DDBJ | mRNA | ||
AB451349 EMBL· GenBank· DDBJ | BAG70163.1 EMBL· GenBank· DDBJ | mRNA | ||
CR536514 EMBL· GenBank· DDBJ | CAG38752.1 EMBL· GenBank· DDBJ | mRNA |