Q6FHW6 · Q6FHW6_HUMAN

  • Protein
    Hepatocyte nuclear factor 1-beta
  • Gene
    TCF2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

Features

Showing features for dna binding.

155750100150200250300350400450500550
TypeIDPosition(s)Description
DNA binding231-311Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentnucleoplasm
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionidentical protein binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanterior/posterior pattern specification
Biological Processbranching morphogenesis of an epithelial tube
Biological Processembryonic digestive tract morphogenesis
Biological Processendodermal cell fate specification
Biological Processepithelial cell proliferation
Biological Processhepatoblast differentiation
Biological Processhindbrain development
Biological Processinner cell mass cell differentiation
Biological Processinsulin secretion
Biological Processmesenchymal cell apoptotic process involved in metanephros development
Biological Processmesonephric duct formation
Biological Processnegative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
Biological Processnegative regulation of mesenchymal cell apoptotic process involved in metanephros development
Biological Processnegative regulation of transcription by RNA polymerase II
Biological ProcessNotch signaling pathway
Biological Processpancreas development
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of branch elongation involved in ureteric bud branching
Biological Processregulation of Wnt signaling pathway
Biological Processresponse to glucose
Biological Processureteric bud elongation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hepatocyte nuclear factor 1-beta
  • Alternative names
    • Transcription factor 2

Gene names

    • Name
      TCF2
    • ORF names
      hCG_27684

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6FHW6

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Organism-specific databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-32HNF-p1
Region64-85Disordered
Domain93-188POU-specific atypical
Domain229-310Homeobox
Region324-352Disordered

Sequence similarities

Belongs to the HNF1 homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    557
  • Mass (Da)
    61,324
  • Last updated
    2005-05-10 v1
  • Checksum
    9E1ECC7423B73980
MVSKLTSLQQELLSALLSSGVTKEVLVQALEELLPSPNFGVKLETLPLSPGSGAEPDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQSHGPGQSDDACSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHSLNPLLSHGSPHHQPSSSPPNKLSGVRYSQQGNNEITSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHNLLSPDGKMISVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQSVPVINSVAGSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSISTLTNMSSSKQCPLQAW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BT007126
EMBL· GenBank· DDBJ
AAP35790.1
EMBL· GenBank· DDBJ
mRNA
AK290131
EMBL· GenBank· DDBJ
BAF82820.1
EMBL· GenBank· DDBJ
mRNA
CR536572
EMBL· GenBank· DDBJ
CAG38809.1
EMBL· GenBank· DDBJ
mRNA
CH471199
EMBL· GenBank· DDBJ
EAW57603.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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