Q6FHL3 · Q6FHL3_HUMAN
- ProteinTranslocating chain-associated membrane protein
- GeneTRAM1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids374 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Biological Process | SRP-dependent cotranslational protein targeting to membrane, translocation |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTranslocating chain-associated membrane protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ6FHL3
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 26-51 | Helical | ||||
Sequence: IVSCVAMVFLLGLMFEITAKASIIFV | ||||||
Transmembrane | 83-102 | Helical | ||||
Sequence: VFFYMLVAIIIHAVIQEYML | ||||||
Transmembrane | 123-147 | Helical | ||||
Sequence: GQLSAFYLFACVWGTFILISENYIS | ||||||
Transmembrane | 167-185 | Helical | ||||
Sequence: FFYISQLAYWLHAFPELYF | ||||||
Transmembrane | 197-214 | Helical | ||||
Sequence: LVYIGLYLFHIAGAYLLN | ||||||
Transmembrane | 220-240 | Helical | ||||
Sequence: LVLLVLHYFVEFLFHISRLFY | ||||||
Transmembrane | 252-274 | Helical | ||||
Sequence: LWAVLFVLGRLLTLILSVLTVGF | ||||||
Transmembrane | 294-316 | Helical | ||||
Sequence: LAVRIAVLASICVTQAFMMWKFI |
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Subunit
Interacts with SEC61B. May interact with Derlin-1/DERL1.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 117-326 | TLC | ||||
Sequence: SKFNESGQLSAFYLFACVWGTFILISENYISDPTILWRAYPHNLMTFQMKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYIGLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSNEKYQKGFSLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAVLASICVTQAFMMWKFINFQLRRWREH | ||||||
Region | 334-374 | Disordered | ||||
Sequence: VKKKPTVTKGRSSKKGTENGVNGTLTSNVADSPRNKKEKSS | ||||||
Compositional bias | 345-364 | Polar residues | ||||
Sequence: SSKKGTENGVNGTLTSNVAD |
Sequence similarities
Belongs to the TRAM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length374
- Mass (Da)43,072
- Last updated2005-05-10 v1
- Checksum9232ADA33DE20076
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 345-364 | Polar residues | ||||
Sequence: SSKKGTENGVNGTLTSNVAD |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BT007359 EMBL· GenBank· DDBJ | AAP36023.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292777 EMBL· GenBank· DDBJ | BAF85466.1 EMBL· GenBank· DDBJ | mRNA | ||
CR541739 EMBL· GenBank· DDBJ | CAG46539.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471068 EMBL· GenBank· DDBJ | EAW86967.1 EMBL· GenBank· DDBJ | Genomic DNA |