Q6F3F9 · AGRG6_MOUSE

  • Protein
    Adhesion G-protein coupled receptor G6
  • Gene
    Adgrg6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein-signaling pathways (PubMed:21613327, PubMed:24227709).
Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis (PubMed:27501152).

ADGRG6 N-terminal fragment

Plays an important role in heart developmention (PubMed:24082093).
Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF (PubMed:25695270).

Features

Showing features for site.

111651002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Site440-441Cleavage; by furin like-convertase
Site810-811Cleavage

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functioncollagen binding
Molecular Functionextracellular matrix binding
Molecular FunctionG protein-coupled receptor activity
Molecular Functionlaminin binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological ProcesscAMP-mediated signaling
Biological Processcell surface receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processheart trabecula formation
Biological Processmitochondrion organization
Biological Processmyelination
Biological Processmyelination in peripheral nervous system

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adhesion G-protein coupled receptor G6
  • Alternative names
    • Developmentally regulated G-protein-coupled receptor
    • G-protein coupled receptor 126
  • Cleaved into 2 chains

Gene names

    • Name
      Adgrg6
    • Synonyms
      Dreg, Gm222, Gpr126

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N-3
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6F3F9
  • Secondary accessions
    • Q811E4

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain31-832Extracellular
Transmembrane833-853Helical; Name=1
Topological domain854-873Cytoplasmic
Transmembrane874-894Helical; Name=2
Topological domain895-899Extracellular
Transmembrane900-920Helical; Name=3
Topological domain921-940Cytoplasmic
Transmembrane941-961Helical; Name=4
Topological domain962-994Extracellular
Transmembrane995-1015Helical; Name=5
Topological domain1016-1039Cytoplasmic
Transmembrane1040-1060Helical; Name=6
Topological domain1061-1062Extracellular
Transmembrane1063-1083Helical; Name=7
Topological domain1084-1165Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Deficient mice die during organogenesis. Mutant embryos show signs of myocardial wall thinning, hypotrabeculation, defective mitochondrial and circulatory failure.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 55 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-30
ChainPRO_000043859831-440ADGRG6 N-terminal fragment
ChainPRO_000030388831-1165Adhesion G-protein coupled receptor G6
Disulfide bond41↔67
Disulfide bond94↔111
Glycosylation121N-linked (GlcNAc...) asparagine
Glycosylation143N-linked (GlcNAc...) asparagine
Disulfide bond186↔254
Glycosylation258N-linked (GlcNAc...) asparagine
Glycosylation314N-linked (GlcNAc...) asparagine
Glycosylation324N-linked (GlcNAc...) asparagine
Glycosylation353N-linked (GlcNAc...) asparagine
Glycosylation370N-linked (GlcNAc...) asparagine
Glycosylation410N-linked (GlcNAc...) asparagine
Glycosylation417N-linked (GlcNAc...) asparagine
Glycosylation424N-linked (GlcNAc...) asparagine
ChainPRO_0000438599441-1165ADGRG6 C-terminal fragment
Glycosylation458N-linked (GlcNAc...) asparagine
Glycosylation462N-linked (GlcNAc...) asparagine
Glycosylation478N-linked (GlcNAc...) asparagine
Glycosylation536N-linked (GlcNAc...) asparagine
Glycosylation549N-linked (GlcNAc...) asparagine
Glycosylation563N-linked (GlcNAc...) asparagine
Glycosylation570N-linked (GlcNAc...) asparagine
Glycosylation665N-linked (GlcNAc...) asparagine
Glycosylation674N-linked (GlcNAc...) asparagine
Glycosylation720N-linked (GlcNAc...) asparagine
Glycosylation746N-linked (GlcNAc...) asparagine
Disulfide bond773↔805
Glycosylation781N-linked (GlcNAc...) asparagine
Glycosylation788N-linked (GlcNAc...) asparagine
Disulfide bond792↔807
Modified residue1135Phosphoserine
Modified residue1138Phosphoserine

Post-translational modification

Proteolytically cleaved into 2 conserved sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an N-terminal fragment (NTF) and a seven-transmembrane-containing C-terminal fragment (CTF). The membrane-bound CTF can act as an independent receptor and the soluble NTF can act as a ligand or coreceptor. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS region occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at high levels in the heart, somite and otic vesicle during embryogenesis and in adult lung.

Gene expression databases

Interaction

Subunit

Interacts with Laminin-2; this interaction stabilizes the receptor in an inactive state (PubMed:25695270).
Laminin-2 polymerization could facilitate ADGRG6-NTF removal, thereby exposing the tethered agonist to drive myelination (PubMed:25695270).
Interacts with PRNP (PubMed:27501152).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, motif.

TypeIDPosition(s)Description
Domain41-149CUB
Region41-355Mediates interaction with type IV collagen
Region41-822Inhibits receptor signaling in absence of type IV collagen
Domain154-356Pentraxin (PTX)
Region446-807Mediates interaction with laminin-2
Domain640-823GAIN-B
Region773-823GPS
Motif812-820STACHEL
Region1126-1165Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,165
  • Mass (Da)
    129,721
  • Last updated
    2004-08-16 v1
  • Checksum
    B5CC5CDEAA42CB50
MMFDTLGKRCCPWRLKPSALLFLFVLCVTCVPLSVCGCGSCRLVLSNPSGTFTSPCYPNDYPNTQSCSWTLRAPAGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSFNSSVNEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTLDAYQVSVAKSISIPELKAFTLCFEASKVGNEGGDWTAFSYSDESLTQLLSLEKASNGYFLSISGSRCLLNNALPVKDKEDIFTENLEQLCLVWNNSWGSIGINFKKNYETVPCDSTISAVVPGDGTLLLGSDRDEVASLRGSIYNFRLWNFTMDLKALSNLSCSVSGNVIDWHNDFWSISTQALKAEGNLSCGSYLIQLPAAELTNCSELGTLCQDGIMYRISVVIHNDFNHPEVKVQTKVAEWLNSTFQNWNYTVYVVNISFHQKVGEDRMKVKRDIMDDDKRLVLWALLVYNATNNVSLNEEKIKQKLMTNNASLEDGLRLCEVDVNQLGMCSALEDPDGFSWPATLPSVYKQPCPNKPGFFMTRACLSNGTSTFWGPVDTSNCSRQSNEVANEILNQTGDGQNLTSANINSIVEKVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSTEALKTIDELAFKIDLNSTPHVNIETQNLALGVSSLIPGTNAPSNFSIGLPSNNESYFQMDFGNGQTDPLASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGSQRKVLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHPICAFWDMNKNKSFGGWNTSGCVAHSDLDAGETICLCSHFTHFGVLMDLPRSASQIDGRNTKVLTFITYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSSALLFLNLIFLLDGWVTSFGVAGLCTAVAALLHFFLLATFTWMGLEAIHMYIALVKVFNTYIHRYILKFCIIGWGLPALVVSIILVSRRQNEVYGKESYGKDQDDEFCWIQDPVVFYVSCAGYFGVMFFLNVAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHSDNFS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A571BEJ4A0A571BEJ4_MOUSEAdgrg61220
A0A140LIH4A0A140LIH4_MOUSEAdgrg61193

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB183545
EMBL· GenBank· DDBJ
BAD27570.1
EMBL· GenBank· DDBJ
mRNA
BC046534
EMBL· GenBank· DDBJ
AAH46534.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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