Q6DLH1 · GH_EHV1B

Function

function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell endosome membrane
Cellular Componenthost cell plasma membrane
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Biological Processfusion of virus membrane with host plasma membrane
Biological Processsymbiont entry into host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Envelope glycoprotein H
  • Short names
    gH

Gene names

    • Name
      gH
    • Ordered locus names
      39

Organism names

Accessions

  • Primary accession
    Q6DLH1
  • Secondary accessions
    • P09101
    • Q66681

Proteomes

Subcellular Location

Virion membrane
; Single-pass type I membrane protein
Host cell membrane
; Single-pass type I membrane protein
Host endosome membrane
; Single-pass type I membrane protein
Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain25-808Virion surface
Transmembrane809-829Helical
Topological domain830-848Intravirion

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_000003823925-848Envelope glycoprotein H
Glycosylation36N-linked (GlcNAc...) asparagine; by host
Glycosylation41N-linked (GlcNAc...) asparagine; by host
Glycosylation45N-linked (GlcNAc...) asparagine; by host
Glycosylation60N-linked (GlcNAc...) asparagine; by host
Glycosylation119N-linked (GlcNAc...) asparagine; by host
Glycosylation182N-linked (GlcNAc...) asparagine; by host
Glycosylation210N-linked (GlcNAc...) asparagine; by host
Glycosylation496N-linked (GlcNAc...) asparagine; by host
Glycosylation672N-linked (GlcNAc...) asparagine; by host
Glycosylation766N-linked (GlcNAc...) asparagine; by host
Glycosylation789N-linked (GlcNAc...) asparagine; by host

Post-translational modification

N-glycosylated, O-glycosylated, and sialylated.

Keywords

PTM databases

Interaction

Subunit

Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.

Structure

3D structure databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region166-191Disordered
Region240-303Interaction with gL

Sequence similarities

Belongs to the herpesviridae glycoprotein H family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    848
  • Mass (Da)
    92,842
  • Last updated
    2004-08-16 v1
  • Checksum
    AD0C64DAE9EA5A7E
MLQPYRKMLIFAVVTVAFAMAVWSTPVPATPSGVGNATWANNSFNITRYDKITMGQVYSNTSNSPIFFVVISERNFRIVNTPLGASVFWIPKGAMNPPQHQPCVANGPEPGDPRGPCVNSTVSLLFNENVEPFLMSKNLLEFEVLPDTYITGWTFERSKTATTKSNPVGVVLSPPRGSPSANTTIRDDGGPKKPLSIIDEYTTLVADLQNFTMTLTYISPFAAVWPIEAFQTGITVMGCDTTQVVAYLGHGFMGLQISSVNNPPLEMIVVPNDVSARILNRRPSRLRLEPPGPHAGPIYKVYVLSDGNFYLGHGMSRISREVAAYPEESLDYRYHLSLANLDTLAMLAELSSGKSTDVSYYMYRIVARLAVATFSLAEVIRLSDYMLLQEAIDVDMNLRLIVPLVMKYAAGGAADSSYTSSDVAMDQFDVAQSQIEKIVSDINVEAELRKPMYEHRSLLRSVYAYSRKPLPNAVALADRLILAMYKEAIKDRITWNSTMREVLFFAVGAAAGSHVILTDEPEPGAPAHKDASLFLSLNRNILLLCTAMCTASHAVSAGLKLEEVMAGLVAGGVQFSLLEVFSPCMASTRFDLAEEEHVLDLLSVIPPRLYTDLNTGFEDDGTTIHSYGRSANGILNSRIAYNFDAVSVFTPELASCSTKLPKVLVVLPIFTNRSYVITRTAPSIGLTYSLDGVNIAKPIVISYITYGNCEVSRATIKSGYLDNPGHTQTCVYCGSVFMRYMVSGAIMDLIYIDDKEVELQLVAGENSTIPAFNPKLYTPSMNALLMFPNGTVTLMSAFASYSSFKVPSTYLWASIGGLLLAILILYIIIKMLCGGVTNDGYKLLLSYE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY665713
EMBL· GenBank· DDBJ
AAT67297.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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