Q6DJQ3 · Q6DJQ3_XENTR
- Protein4-trimethylaminobutyraldehyde dehydrogenase
- Genealdh9a1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids498 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
Catalytic activity
- (5-hydroxyindol-3-yl)acetaldehyde + NAD+ + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H+
- 3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O = 3,4-dihydroxyphenylacetate + NADH + 2 H+
- pentanal + NAD+ + H2O = pentanoate + NADH + 2 H+
- propanal + NAD+ + H2O = propanoate + NADH + 2 H+
- spermine monoaldehyde + NAD+ + H2O = N-(2-carboxyethyl)spermidine + NADH + 2 H+
- hexanal + NAD+ + H2O = hexanoate + NADH + 2 H+
- imidazole-4-acetaldehyde + NAD+ + H2O = imidazole-4-acetate + NADH + 2 H+
- acrolein + NAD+ + H2O = acrylate + NADH + 2 H+
- butanal + NAD+ + H2O = butanoate + NADH + 2 H+
Pathway
Amine and polyamine biosynthesis; carnitine biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 258 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-trimethylaminobutyraldehyde dehydrogenase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionQ6DJQ3
Proteomes
Organism-specific databases
Structure
Sequence
- Sequence statusComplete
- Length498
- Mass (Da)54,051
- Last updated2004-08-16 v1
- MD5 ChecksumC8418DFDB206FE1FB8334BBFA116407B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC075121 EMBL· GenBank· DDBJ | AAH75121.1 EMBL· GenBank· DDBJ | mRNA | ||
CR760688 EMBL· GenBank· DDBJ | CAJ82214.1 EMBL· GenBank· DDBJ | mRNA |