Q6DIA9 · FBX27_MOUSE

  • Protein
    F-box only protein 27
  • Gene
    Fbxo27
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular ComponentSCF ubiquitin ligase complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    F-box only protein 27

Gene names

    • Name
      Fbxo27

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q6DIA9
  • Secondary accessions
    • Q3TYP0
    • Q8BKF7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001199161-280F-box only protein 27

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in brain, heart and muscle.

Gene expression databases

Interaction

Subunit

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-67F-box
Domain101-277FBA

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6DIA9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    280
  • Mass (Da)
    31,633
  • Last updated
    2004-08-16 v1
  • Checksum
    36FF90947DFAE86B
MGAWISRTRVPTPEPDPQEVLDLSRLPPELLLLVLSHVPPRTLLMHCRRVCRAWRALVDGQALWLLLLARDHSAAGRALLTLARRCLPPAHEDTPCPLGQFCALRPLGRNLISNPCGQEGLRKWMVRHGGDGWVVEKNRKPVPGAPSQTCFVTSFSWCRKKQVVDLVEKGLWPELLDSGGVEIAVSDWWGARHDSGCKYRLFVTLLDAHQNVIDKFSAVPDPIEQWNNDIYLQVTHVFSGIRRGIRFVSFEHWGQDTQFWAGHYGARVTNSSVIIRVCQS

Q6DIA9-2

  • Name
    2
  • Note
    May be due to a competing acceptor splice site.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z3I2D3Z3I2_MOUSEFbxo2773
Q3TEI7Q3TEI7_MOUSEFbxo27156
A0A140LHU7A0A140LHU7_MOUSEFbxo2746

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_013054119in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK053292
EMBL· GenBank· DDBJ
BAC35334.1
EMBL· GenBank· DDBJ
mRNA
AK140275
EMBL· GenBank· DDBJ
BAE24311.1
EMBL· GenBank· DDBJ
mRNA
AK158463
EMBL· GenBank· DDBJ
BAE34522.1
EMBL· GenBank· DDBJ
mRNA
BC075656
EMBL· GenBank· DDBJ
AAH75656.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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