Q6DHI1 · ZDHC7_DANRE
- ProteinPalmitoyltransferase ZDHHC7
- Genezdhhc7
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids299 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable).
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
- L-cysteinyl-[protein] + tetradecanoyl-CoA = CoA + S-tetradecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
- L-cysteinyl-[protein] + octadecanoyl-CoA = CoA + S-octadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 151 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Molecular Function | protein-cysteine S-myristoyltransferase activity | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Molecular Function | protein-cysteine S-stearoyltransferase activity | |
Molecular Function | S-acyltransferase activity | |
Biological Process | peptidyl-L-cysteine S-palmitoylation | |
Biological Process | protein targeting to membrane | |
Biological Process | regulation of protein localization to cell-cell junction | |
Biological Process | regulation of protein localization to plasma membrane |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase ZDHHC7
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6DHI1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-41 | Cytoplasmic | ||||
Sequence: MQSSGQRLRDVEQHQPLLSGGEEEVTAGRVWFIQDSCGMVC | ||||||
Transmembrane | 42-62 | Helical | ||||
Sequence: AFMTWSLVMYAEFVVNFVMLL | ||||||
Topological domain | 63-66 | Lumenal | ||||
Sequence: PSKN | ||||||
Transmembrane | 67-87 | Helical | ||||
Sequence: FWYTLINGVAFNFLAVLALTS | ||||||
Topological domain | 88-164 | Cytoplasmic | ||||
Sequence: HLRTMLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCSIKPERAHHCSICKRCIRKMDHHCPWVNNCVGENNQR | ||||||
Transmembrane | 165-185 | Helical | ||||
Sequence: FFVLFTMYIASISLHALCLSG | ||||||
Topological domain | 186-208 | Lumenal | ||||
Sequence: FHFFTCVKVQWNECSDFSPPVAV | ||||||
Transmembrane | 209-229 | Helical | ||||
Sequence: MLLIFLCLEALLFLTFTAVMF | ||||||
Topological domain | 230-299 | Cytoplasmic | ||||
Sequence: GTQIHSICNDETEIERLKNEKPTWERRVRWDGMKAVFGGPPSLLWFNPFAGLRLRMLMVRARRSGAEFSV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000449797 | 1-299 | Palmitoyltransferase ZDHHC7 | |||
Sequence: MQSSGQRLRDVEQHQPLLSGGEEEVTAGRVWFIQDSCGMVCAFMTWSLVMYAEFVVNFVMLLPSKNFWYTLINGVAFNFLAVLALTSHLRTMLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCSIKPERAHHCSICKRCIRKMDHHCPWVNNCVGENNQRFFVLFTMYIASISLHALCLSGFHFFTCVKVQWNECSDFSPPVAVMLLIFLCLEALLFLTFTAVMFGTQIHSICNDETEIERLKNEKPTWERRVRWDGMKAVFGGPPSLLWFNPFAGLRLRMLMVRARRSGAEFSV |
Post-translational modification
Autopalmitoylated.
Keywords
- PTM
Proteomic databases
Expression
Developmental stage
Probably maternally supplied. No zygotic expression is detected before 7.5 hpf.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 122-171 | DHHC | ||||
Sequence: KCPKCCSIKPERAHHCSICKRCIRKMDHHCPWVNNCVGENNQRFFVLFTM |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)34,191
- Last updated2004-08-16 v1
- ChecksumD9D66CCE8CBB1842
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU927919 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC075993 EMBL· GenBank· DDBJ | AAH75993.1 EMBL· GenBank· DDBJ | mRNA |