Q6DHE8 · RHOAD_DANRE
- ProteinRho-related GTP-binding protein RhoA-D
- Generhoad
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids193 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-19 | GTP (UniProtKB | ChEBI) | ||||
Sequence: GDGACGKT | ||||||
Binding site | 30-37 | GTP (UniProtKB | ChEBI) | ||||
Sequence: FPEVYVPT | ||||||
Binding site | 59-63 | GTP (UniProtKB | ChEBI) | ||||
Sequence: DTAGQ | ||||||
Binding site | 117-120 | GTP (UniProtKB | ChEBI) | ||||
Sequence: NKKD | ||||||
Binding site | 160-162 | GTP (UniProtKB | ChEBI) | ||||
Sequence: SAK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | protein kinase binding | |
Biological Process | actin filament organization | |
Biological Process | mitotic cytokinesis | |
Biological Process | regulation of actin cytoskeleton organization | |
Biological Process | signal transduction | |
Biological Process | skeletal muscle satellite cell migration | |
Biological Process | small GTPase-mediated signal transduction | |
Biological Process | wound healing, spreading of cells |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRho-related GTP-binding protein RhoA-D
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6DHE8
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000434741 | 1-190 | Rho-related GTP-binding protein RhoA-D | |||
Sequence: MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDSKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELIKMKQEPVKPEEGRDMANRISAFGYLECSAKTKDGVREVFEMATRAALQVRKRKKRSGC | ||||||
Glycosylation | 34 | (Microbial infection) O-linked (GlcNAc) tyrosine; by Yersinia Afp18 | ||||
Sequence: Y | ||||||
Modified residue | 190 | Cysteine methyl ester | ||||
Sequence: C | ||||||
Lipidation | 190 | S-geranylgeranyl cysteine | ||||
Sequence: C | ||||||
Propeptide | PRO_0000434742 | 191-193 | Removed in mature form | |||
Sequence: LLL |
Post-translational modification
(Microbial infection) Glycosylated at Tyr-34 by Yersinia ruckeri toxin Afp18. Mono-O-GlcNAcylation by Afp18 inhibits RhoA activation by guanine nucleotide exchange factors and blocks RhoA signaling.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length193
- Mass (Da)21,993
- Last updated2004-08-16 v1
- ChecksumEE6146B227B148C8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY865557 EMBL· GenBank· DDBJ | AAX20129.1 EMBL· GenBank· DDBJ | mRNA | ||
AL954868 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX323059 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC076026 EMBL· GenBank· DDBJ | AAH76026.1 EMBL· GenBank· DDBJ | mRNA |