Q6DGS3 · KC2D2_DANRE
- ProteinCalcium/calmodulin-dependent protein kinase type II delta 2 chain
- Genecamk2d2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids554 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Activity regulation
Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 19-27 | ATP (UniProtKB | ChEBI) | |||
Binding site | 42 | ATP (UniProtKB | ChEBI) | |||
Active site | 135 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | neuron projection | |
Molecular Function | ATP binding | |
Molecular Function | calcium/calmodulin-dependent protein kinase activity | |
Molecular Function | calmodulin binding | |
Molecular Function | protein serine kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium/calmodulin-dependent protein kinase type II delta 2 chain
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6DGS3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000277821 | 1-554 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain | ||
Modified residue | 286 | Phosphothreonine | |||
Modified residue | 314 | Phosphoserine | |||
Modified residue | 318 | Phosphoserine | |||
Modified residue | 372 | Phosphothreonine | |||
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
First detected at 18 hpf. At 24 hpf, expressed in discrete anterior locations and along either side of the midline. At 48 hpf, expression is predominantly in the forebrain, and then accumulates in the forebrain, hindbrain, and retinal epithelium at 72 hpf.
Interaction
Subunit
CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 13-271 | Protein kinase | |||
Region | 324-375 | Disordered | |||
Compositional bias | 360-375 | Basic and acidic residues | |||
Region | 392-413 | Disordered | |||
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q6DGS3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameO
- Length554
- Mass (Da)62,384
- Last updated2008-10-14 v2
- MD5 Checksum0182F3345AF0E35D5CFEE7C13535CBDF
Q6DGS3-2
- NameA
- Differences from canonical
- 379-419: Missing
Q6DGS3-3
- NameE
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6YWG3 | A0A8M6YWG3_DANRE | camk2d2 | 554 | ||
A0A8M6YVY0 | A0A8M6YVY0_DANRE | camk2d2 | 512 | ||
A0A8M9P897 | A0A8M9P897_DANRE | camk2d2 | 547 | ||
A0A8M9PY32 | A0A8M9PY32_DANRE | camk2d2 | 500 | ||
A0A8M2B6H3 | A0A8M2B6H3_DANRE | camk2d2 | 492 | ||
A0A8M3B4L7 | A0A8M3B4L7_DANRE | camk2d2 | 534 | ||
A0A8M9P8T6 | A0A8M9P8T6_DANRE | camk2d2 | 512 | ||
A0A8M3AYB7 | A0A8M3AYB7_DANRE | camk2d2 | 520 | ||
A0A8M3AYD5 | A0A8M3AYD5_DANRE | camk2d2 | 533 | ||
A0A8M3AYD9 | A0A8M3AYD9_DANRE | camk2d2 | 513 | ||
F1QGL7 | F1QGL7_DANRE | camk2d2 | 554 | ||
A0A8M3B7E7 | A0A8M3B7E7_DANRE | camk2d2 | 553 | ||
A0A8M3B7F4 | A0A8M3B7F4_DANRE | camk2d2 | 519 |
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 266 | in Ref. 1; AAI54769 | |||
Alternative sequence | VSP_035556 | 329-348 | in isoform E | ||
Compositional bias | 360-375 | Basic and acidic residues | |||
Alternative sequence | VSP_035557 | 379-419 | in isoform A and isoform E | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC076266 EMBL· GenBank· DDBJ | AAH76266.1 EMBL· GenBank· DDBJ | mRNA | ||
BC154768 EMBL· GenBank· DDBJ | AAI54769.1 EMBL· GenBank· DDBJ | mRNA |