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Q6DGS3 · KC2D2_DANRE

Function

function

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.

Catalytic activity

Activity regulation

Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site19-27ATP (UniProtKB | ChEBI)
Binding site42ATP (UniProtKB | ChEBI)
Active site135Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentneuron projection
Molecular FunctionATP binding
Molecular Functioncalcium/calmodulin-dependent protein kinase activity
Molecular Functioncalmodulin binding
Molecular Functionprotein serine kinase activity
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium/calmodulin-dependent protein kinase type II delta 2 chain
  • EC number
  • Alternative names
    • Calcium/calmodulin-dependent protein kinase type II delta-A chain (CaM kinase II subunit delta-A; CaM-kinase II delta-A chain; CaMK-II subunit delta-A)

Gene names

    • Name
      camk2d2
    • Synonyms
      camk2d, camk2da
    • ORF names
      zgc:92792

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6DGS3
  • Secondary accessions
    • A8WGM2

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002778211-554Calcium/calmodulin-dependent protein kinase type II delta 2 chain
Modified residue286Phosphothreonine
Modified residue314Phosphoserine
Modified residue318Phosphoserine
Modified residue372Phosphothreonine

Keywords

Proteomic databases

Expression

Tissue specificity

First detected at 18 hpf. At 24 hpf, expressed in discrete anterior locations and along either side of the midline. At 48 hpf, expression is predominantly in the forebrain, and then accumulates in the forebrain, hindbrain, and retinal epithelium at 72 hpf.

Interaction

Subunit

CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain13-271Protein kinase
Region324-375Disordered
Compositional bias360-375Basic and acidic residues
Region392-413Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q6DGS3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    554
  • Mass (Da)
    62,384
  • Last updated
    2008-10-14 v2
  • MD5 Checksum
    0182F3345AF0E35D5CFEE7C13535CBDF
MALTICTRFTDEYQLFEELGKGAFSVVRRCVKISSGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHVNGIVHRDLKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEAPKHPWICQRSTVASMMHRQETVECLKKFNARRKLKGAILTTLLVTRNFSAAKSLLNKKPDGVKVNNKTNLASSPKDTGPAPALEPQTTVIHNPVDRNKESTESANTTIEDEDLKARRFGNLSINSIWQPSVGRPQNSEPKQAPNSSVQTCQVINKARKQEIIKVTEQLIESINNGDFEAYAKICDPGLTSFEPEALGNLVEGHDFHRFYFENALSKGNKPVHTILLNPHVHLIGEDAACIAYIRLTQYMDGSGMPRTMQSEETRVWHRRDGKWLNIHFHRSGAPSVPIN

Q6DGS3-2

  • Name
    A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6DGS3-3

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6YWG3A0A8M6YWG3_DANREcamk2d2554
A0A8M6YVY0A0A8M6YVY0_DANREcamk2d2512
A0A8M9P897A0A8M9P897_DANREcamk2d2547
A0A8M9PY32A0A8M9PY32_DANREcamk2d2500
A0A8M2B6H3A0A8M2B6H3_DANREcamk2d2492
A0A8M3B4L7A0A8M3B4L7_DANREcamk2d2534
A0A8M9P8T6A0A8M9P8T6_DANREcamk2d2512
A0A8M3AYB7A0A8M3AYB7_DANREcamk2d2520
A0A8M3AYD5A0A8M3AYD5_DANREcamk2d2533
A0A8M3AYD9A0A8M3AYD9_DANREcamk2d2513
F1QGL7F1QGL7_DANREcamk2d2554
A0A8M3B7E7A0A8M3B7E7_DANREcamk2d2553
A0A8M3B7F4A0A8M3B7F4_DANREcamk2d2519

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

Type
IDPosition(s)Description
Sequence conflict266in Ref. 1; AAI54769
Alternative sequenceVSP_035556329-348in isoform E
Compositional bias360-375Basic and acidic residues
Alternative sequenceVSP_035557379-419in isoform A and isoform E

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC076266
EMBL· GenBank· DDBJ
AAH76266.1
EMBL· GenBank· DDBJ
mRNA
BC154768
EMBL· GenBank· DDBJ
AAI54769.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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