Q6DG03 · DMTF1_DANRE

Function

function

Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'.

Features

Showing features for dna binding.

164550100150200250300350400450500550600
TypeIDPosition(s)Description
DNA binding300-323H-T-H motif

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-D-binding Myb-like transcription factor 1

Gene names

    • Name
      dmtf1
    • ORF names
      si:dkey-153k10.8, zgc:92448

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6DG03
  • Secondary accessions
    • Q5RGE9

Proteomes

    • Identifier
    • Component
      Alternate scaffold 4, Chromosome 4

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003237321-645Cyclin-D-binding Myb-like transcription factor 1

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region34-71Disordered
Compositional bias43-61Basic and acidic residues
Region95-119Disordered
Domain219-257Myb-like 1
Domain262-327HTH myb-type
Domain333-382Myb-like 2
Region568-645Disordered
Compositional bias570-585Polar residues
Compositional bias615-629Polar residues

Sequence similarities

Belongs to the DMTF1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q6DG03-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    645
  • Mass (Da)
    71,268
  • Last updated
    2004-08-16 v1
  • Checksum
    AB5832B045A7861B
MNTGDVPATVTLESVNSVTFTQDTDGNIILHCPQNDGEDLGSDETTEPVHKRIRLSSEDGEDPQDSASTEYSVVTLPITDGDESFEVTMTATEMRDEELESDDLSETTGKDSSAQKKGEDVSAVSQAWFTTKEDKDTLVNKGHKWKQGMWSKEEIDLLMTNIELYLKNRGIQDPAEIIFEMSKEERKDFYRSIACGLNRPLFAVYRRVLRMYDNRNHVGKYTDEEINKLKELRQKHGNDWATIGSALGRSASSVKDRCRLMKDTCNTGKWTEEEERRLAEVVHELTGTEAGDVVTQGVSWASVAELVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDDINLVRRIAELEVEDENEINWDILASGWSSVRSPQWLRSKWWTIKRQVANHKELPFPVLLKGLQDVVEAPPSTMNKVVVVGSRSANASPSPVTALQIPVQIPVQITHVSSSDGSSGTSDSETITLNSGALQTFELLPSFHLQPTGTPGTYFLQTGTNQSLPLTLSANPTVTLTAAASPSSPDQIILHSLTTDTENVTVQMSHPGIIIQTVTSEDLADPLGQSELEGEQVLVKEEPSENQTNPAIEEPSEEQSKQGEKTLDSSKVVETVLMVPSPGSFIPTNEDISSDSVLPLGTLTDPILENQEEGSN

Q6DG03-2

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias43-61Basic and acidic residues
Alternative sequenceVSP_034966395in isoform 2
Alternative sequenceVSP_034967396-446in isoform 2
Alternative sequenceVSP_034968528-531in isoform 2
Compositional bias570-585Polar residues
Compositional bias615-629Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX901962
EMBL· GenBank· DDBJ
CAI20680.2
EMBL· GenBank· DDBJ
Genomic DNA
BC076552
EMBL· GenBank· DDBJ
AAH76552.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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