Q6DEI9 · Q6DEI9_DANRE
- ProteinProstaglandin reductase 2
- Geneptgr2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids386 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
Catalytic activity
- 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+This reaction proceeds in the backward direction.
- 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+This reaction proceeds in the backward direction.
- 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + NADPH + H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity | |
Biological Process | prostaglandin metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin reductase 2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6DEI9
Organism-specific databases
Subcellular Location
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 55-382 | Enoyl reductase (ER) | ||||
Sequence: GQPVKENFRVEETTTSSELKEGQVLVRTLYLSVDPYMRCRMNDDTGADYLLPWRLEECVDGGGVGVVKASKNPDLSVGTIVTSFNWHWQTYDVMDGSLLQKVDPGMVDGHVSYFLGAVGMPGLTAFFGVREKGHVTAGAQQTMVVSGAAGACGSVAGQIGRLDGCKTVVGICGSDQKCQTLVKELGFTAGINYRNGDVSSALREHCPRGIDIYFDNVGGPISDAVISQMNPGAHVILCGQISQYNKDVPYPPPLSQDTQDALRRNNITRERFIVLNYMEKHAEGLMQLSHWVKTGQIKVLETVVNGIQNMGEAFCSMMTGGNIGKQVV |
Sequence similarities
Belongs to the NADP-dependent oxidoreductase L4BD family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length386
- Mass (Da)42,227
- Last updated2004-08-16 v1
- Checksum7D5753B294E6A3EA
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: G |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC077125 EMBL· GenBank· DDBJ | AAH77125.1 EMBL· GenBank· DDBJ | mRNA |