Q6DEI9 · Q6DEI9_DANRE

Function

function

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

Catalytic activity

  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E2 + NAD+ = 15-oxoprostaglandin E2 + NADH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.48 (UniProtKB | ENZYME | Rhea)
  • 13,14-dihydro-15-oxo-prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.48 (UniProtKB | ENZYME | Rhea)
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + NADPH + H+
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
Biological Processprostaglandin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 2
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase

Gene names

    • Name
      ptgr2
    • Synonyms
      im:6903726
      , si:dkey-119a7.6

Organism names

  • Taxonomic identifier
  • Strain
    • Singapore local strain
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q6DEI9

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain55-382Enoyl reductase (ER)

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    386
  • Mass (Da)
    42,227
  • Last updated
    2004-08-16 v1
  • Checksum
    7D5753B294E6A3EA
GDFRKKHSFCKQGSCFVNICKCCTDIYFFFNFVNKKEKMLNVTRVVLSSRPGNNGQPVKENFRVEETTTSSELKEGQVLVRTLYLSVDPYMRCRMNDDTGADYLLPWRLEECVDGGGVGVVKASKNPDLSVGTIVTSFNWHWQTYDVMDGSLLQKVDPGMVDGHVSYFLGAVGMPGLTAFFGVREKGHVTAGAQQTMVVSGAAGACGSVAGQIGRLDGCKTVVGICGSDQKCQTLVKELGFTAGINYRNGDVSSALREHCPRGIDIYFDNVGGPISDAVISQMNPGAHVILCGQISQYNKDVPYPPPLSQDTQDALRRNNITRERFIVLNYMEKHAEGLMQLSHWVKTGQIKVLETVVNGIQNMGEAFCSMMTGGNIGKQVVKISD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC077125
EMBL· GenBank· DDBJ
AAH77125.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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