Q6DD20 · Q6DD20_XENLA
- ProteinProstaglandin G/H synthase 2
- Geneptgs2.S
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids604 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
- (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2OThis reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; prostaglandin biosynthesis.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | dioxygenase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | peroxidase activity | |
Molecular Function | prostaglandin-endoperoxide synthase activity | |
Biological Process | prostaglandin biosynthetic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProstaglandin G/H synthase 2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionQ6DD20
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Microsome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MIVLPAAVFLALLVFSQA | ||||||
Chain | PRO_5033206831 | 19-604 | Prostaglandin G/H synthase 2 | |||
Sequence: ANPCCSNPCQNQGVCMTVGFDRYECDCTRTGFYGENCTKPEFLSWLRLKLKPTPNTVHYILSHFKGVWNIVNSMSFLRDAIMRYVLTSRSHLIDSPPTYNSHYTYKNWETYSNLSYYTRSLPPVERDCPTPMGVKGLKELPSSKLVVEKFLMRRKFIPDPQGTNVMFAFFAQHFTHQFFKTDMAKGAAFTKALGHGVDLNHVYGESLERQHKLRLMKGGKLKYQMIDGDMYPPTVKSSGVDMAYPPHVPEHVQFAVGQEVFGLVPGLMMYSTIWLREHNRVCDILAGEHPEWDDERIFQTARLILIGETIKIVIEDYVQHLSGYHFKLKFDPQLLFNQRFQYQNRIAAEFNTLYHWHPLLPDTFAINEKEYSYPQFLYNNSVMIDHGLTQMVESFSRQSAGRVAGGRNFPAAITRVAVASIEHSREMRYQSLNEYRKRFMLKPFETFEELTGEKEMSAELEKLYGDIDAMELYPGLLVEQPRPGAIFGETMVEMGAPFSLKGLMGNPICSPEYWKPSTFGGSVGFDIVNSASFQKLICNNVRDCPYTAFHVLKNKPSGKDFINASSDSTLENVKPSLILKEHTSEL |
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 18-56 | EGF-like | ||||
Sequence: AANPCCSNPCQNQGVCMTVGFDRYECDCTRTGFYGENCT |
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length604
- Mass (Da)69,044
- Last updated2004-08-16 v1
- Checksum1A1FFBF0B0BEFAFC
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC077809 EMBL· GenBank· DDBJ | AAH77809.1 EMBL· GenBank· DDBJ | mRNA |