Q6DD20 · Q6DD20_XENLA

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Lipid metabolism; prostaglandin biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site107substrate
Active site194Proton acceptor
Active site372For cyclooxygenase activity
Binding site375Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondioxygenase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxidase activity
Molecular Functionprostaglandin-endoperoxide synthase activity
Biological Processprostaglandin biosynthetic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin G/H synthase 2
  • EC number
  • Alternative names
    • Cyclooxygenase-2
    • PHS II
    • Prostaglandin H2 synthase 2
    • Prostaglandin-endoperoxide synthase 2

Gene names

    • Name
      ptgs2.S
    • Synonyms
      cox-2
      , cox2
      , gripghs
      , pgg/hs
      , pghs-2
      , phs-2
      , ptgs2
      , ptgs2-prov
      , ptgs2.L

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q6DD20

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Peripheral membrane protein
Membrane
; Peripheral membrane protein
Microsome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_503320683119-604Prostaglandin G/H synthase 2

Expression

Gene expression databases

    • 446781Expressed in gastrula and 15 other cell types or tissues

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-56EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    604
  • Mass (Da)
    69,044
  • Last updated
    2004-08-16 v1
  • Checksum
    1A1FFBF0B0BEFAFC
MIVLPAAVFLALLVFSQAANPCCSNPCQNQGVCMTVGFDRYECDCTRTGFYGENCTKPEFLSWLRLKLKPTPNTVHYILSHFKGVWNIVNSMSFLRDAIMRYVLTSRSHLIDSPPTYNSHYTYKNWETYSNLSYYTRSLPPVERDCPTPMGVKGLKELPSSKLVVEKFLMRRKFIPDPQGTNVMFAFFAQHFTHQFFKTDMAKGAAFTKALGHGVDLNHVYGESLERQHKLRLMKGGKLKYQMIDGDMYPPTVKSSGVDMAYPPHVPEHVQFAVGQEVFGLVPGLMMYSTIWLREHNRVCDILAGEHPEWDDERIFQTARLILIGETIKIVIEDYVQHLSGYHFKLKFDPQLLFNQRFQYQNRIAAEFNTLYHWHPLLPDTFAINEKEYSYPQFLYNNSVMIDHGLTQMVESFSRQSAGRVAGGRNFPAAITRVAVASIEHSREMRYQSLNEYRKRFMLKPFETFEELTGEKEMSAELEKLYGDIDAMELYPGLLVEQPRPGAIFGETMVEMGAPFSLKGLMGNPICSPEYWKPSTFGGSVGFDIVNSASFQKLICNNVRDCPYTAFHVLKNKPSGKDFINASSDSTLENVKPSLILKEHTSEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC077809
EMBL· GenBank· DDBJ
AAH77809.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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