Q6CU02 · ATG15_KLULA
- ProteinPutative lipase ATG15
- GeneATG15
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids531 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).
Catalytic activity
- a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 340 | Charge relay system | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | multivesicular body membrane | |
Molecular Function | phospholipase activity | |
Molecular Function | triacylglycerol lipase activity | |
Biological Process | multivesicular body membrane disassembly | |
Biological Process | neutral lipid catabolic process | |
Biological Process | piecemeal microautophagy of the nucleus |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePutative lipase ATG15
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Kluyveromyces
Accessions
- Primary accessionQ6CU02
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endosome, multivesicular body membrane ; Single-pass type II membrane protein
Prevacuolar compartment membrane ; Single-pass type II membrane protein
Note: From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-11 | Cytoplasmic | |||
Transmembrane | 12-31 | Helical; Signal-anchor for type II membrane protein | |||
Topological domain | 32-531 | Lumenal | |||
Keywords
- Cellular component
Interaction
Subunit
Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 482-513 | Disordered | |||
Compositional bias | 488-513 | Polar residues | |||
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length531
- Mass (Da)58,819
- Last updated2004-08-16 v1
- MD5 Checksum42A351863F1630EA8E53F8C0C7D7F34B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 488-513 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR382123 EMBL· GenBank· DDBJ | CAH01438.1 EMBL· GenBank· DDBJ | Genomic DNA |