Q6BS08 · ATG1_DEBHA

Function

function

Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site28-36ATP (UniProtKB | ChEBI)
Binding site51ATP (UniProtKB | ChEBI)
Active site168Proton acceptor

GO annotations

AspectTerm
Cellular Componentautophagosome
Cellular Componentcytosol
Cellular Componentphagophore assembly site membrane
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionprotein serine kinase activity
Biological Processautophagosome assembly
Biological Processautophagy of mitochondrion
Biological Processpeptidyl-serine phosphorylation
Biological Processpiecemeal microautophagy of the nucleus
Biological Processprotein autophosphorylation
Biological Processprotein transport
Biological Processregulation of autophagy
Biological Processresponse to starvation
Biological Processreticulophagy

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase ATG1
  • EC number
  • Alternative names
    • Autophagy-related protein 1

Gene names

    • Name
      ATG1
    • Ordered locus names
      DEHA2D12452g

Organism names

Accessions

  • Primary accession
    Q6BS08

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000856451-875Serine/threonine-protein kinase ATG1

Interaction

Subunit

Homodimer. Forms a ternary complex with ATG13 and ATG17.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain22-318Protein kinase
Region367-422Disordered
Compositional bias391-406Basic and acidic residues
Compositional bias408-422Polar residues
Region470-515Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    875
  • Mass (Da)
    97,889
  • Last updated
    2008-12-16 v2
  • MD5 Checksum
    E38FD91012BD149CF2C5CD5B7C43E7FF
MSTTSIESNNDIGRSVKTIGVYSIGPEIGKGSFATVYKCFNTKTNESVAIKSVVRSKLKSKKLVENLEIEISILKTMKHPHIVGLLDYKQTTSHFHLVMDYCSMGDLSYFIRKRNQLIKTHPVISSLLERYPSPEGSHGLNEVLVIHFLKQLVSALEFLRNKSLVHRDIKPQNLLLCPPLHSKQEFKDGGFVGLWELPLLKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFRADNHVQLLKNIEKSNDRIKFPSAAQVPESLKRLIRSLLKYNPTERVSFNEFFNDPLIVNDLEGNDEPLETSEMDENLFISEYISPIKSSQKSQYIEPITTEVAVKEKSKQDLPAREVSTHASESQTKAVDTRPSSRDEEIKEIINKNSPGPETSRSIQPHNLKEKSLVLKNKDNDIILERDYVVVEKRAVEVNAIADELAHAGSGAVAINPRRTSSGSDNSYNGPNNMQLYRRPSLRSNSSGSQRRPSFTDRRISISISPTNALTKAIGLASNRLFGVNASGSPTNRLIEETDERLAINENNSSMNATNNTFSTILSNPNFANNLLIQKLNLPTSATVANNSQTNTSPQLSPQSKTDESVLNRLESLATKAHAINLFADVKFSQLIPSPPSSDALDDDLLHQNDMLPPKIVKSISEEGVVLYVKTLSLLAKGMVIASDWWYSQFEIDDPSNKNSNENPLKQSSNNNSDDLSLAVRINELVQWIREKFNECLEKAEFIRLTLQEANTLLSNEDSSEYMGNSNSVADKTRVVAEKLIFDRALEMSRNAAVNELVKEDLKGCELAYSTAIWMLEALLDEDSSNDEDRLDDEDKAMVEKFIVSIGNRLSVLKRKLEVV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias391-406Basic and acidic residues
Compositional bias408-422Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR382136
EMBL· GenBank· DDBJ
CAG87180.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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