Q6BS08 · ATG1_DEBHA
- ProteinSerine/threonine-protein kinase ATG1
- GeneATG1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids875 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 28-36 | ATP (UniProtKB | ChEBI) | |||
Binding site | 51 | ATP (UniProtKB | ChEBI) | |||
Active site | 168 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome | |
Cellular Component | cytosol | |
Cellular Component | phagophore assembly site membrane | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | autophagosome assembly | |
Biological Process | autophagy of mitochondrion | |
Biological Process | peptidyl-serine phosphorylation | |
Biological Process | piecemeal microautophagy of the nucleus | |
Biological Process | protein autophosphorylation | |
Biological Process | protein transport | |
Biological Process | regulation of autophagy | |
Biological Process | response to starvation | |
Biological Process | reticulophagy |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase ATG1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Debaryomyces
Accessions
- Primary accessionQ6BS08
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Preautophagosomal structure membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000085645 | 1-875 | Serine/threonine-protein kinase ATG1 | ||
Interaction
Subunit
Homodimer. Forms a ternary complex with ATG13 and ATG17.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 22-318 | Protein kinase | |||
Region | 367-422 | Disordered | |||
Compositional bias | 391-406 | Basic and acidic residues | |||
Compositional bias | 408-422 | Polar residues | |||
Region | 470-515 | Disordered | |||
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length875
- Mass (Da)97,889
- Last updated2008-12-16 v2
- MD5 ChecksumE38FD91012BD149CF2C5CD5B7C43E7FF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 391-406 | Basic and acidic residues | |||
Compositional bias | 408-422 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR382136 EMBL· GenBank· DDBJ | CAG87180.2 EMBL· GenBank· DDBJ | Genomic DNA |