Q6AYH1 · Q6AYH1_RAT

  • Protein
    Poly(A) polymerase
  • Gene
    Papolb
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Polymerase that creates the 3'-poly(A) tail of mRNA's.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions. Also active with manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

164250100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site101-103ATP (UniProtKB | ChEBI)
Binding site110ATP (UniProtKB | ChEBI)
Binding site114Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site114Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site114-116ATP (UniProtKB | ChEBI)
Binding site116Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site116Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site168ATP (UniProtKB | ChEBI)
Binding site168Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site229ATP (UniProtKB | ChEBI)
Binding site238ATP (UniProtKB | ChEBI)
Binding site247-248ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpoly(A) RNA polymerase activity
Molecular FunctionRNA binding
Biological ProcessmRNA processing
Biological ProcessRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Poly(A) polymerase
  • EC number

Gene names

    • Name
      Papolb
    • ORF names
      rCG_42541

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BN
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q6AYH1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues
Region1-23Disordered
Domain22-215Poly(A) polymerase nucleotidyltransferase
Domain220-364Poly(A) polymerase central
Domain367-435Poly(A) polymerase RNA-binding
Region532-552Disordered
Region620-642Disordered

Sequence similarities

Belongs to the poly(A) polymerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    642
  • Mass (Da)
    72,339
  • Last updated
    2004-09-13 v1
  • Checksum
    78E8E2AA201588FC
MMPFAVTTQGAQQPAPAPKQYGISSPISLAAPKDTDRELTQKLIETLQPFGVFEEEEELQRRILILQKLNNLVKEWIREISESRNLPQAVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRNDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDSFRLTLRAIKLWAKCHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVRKFFLVFSEWEWPNPVLLKEPEERNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMIEEFKQGLAITHEILLNKAEWSKLFEAPSFFQKYKHYIVLLASAPTEKQHLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKENVDKEEFRTMWVIGLVLKKPENSEILSIDLTYDIQSFTDTVYRQAINSKMFEMDMKIAAMHLRRKELHQLLPNHVLQKKETHLTEGVRLTAVNDSSLLLSIDSENSMTAPSPTGTIKTGPLTANPQGRNSPALAVMAASVTNIQFPDVSLQHVNPIESSGIALSESIAQIPSQPTISPPPKPTMTRVVSSTHLVNHPSRPSGNTATNIPNPILGV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC079046
EMBL· GenBank· DDBJ
AAH79046.1
EMBL· GenBank· DDBJ
mRNA
CH474012
EMBL· GenBank· DDBJ
EDL89711.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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