Q6AYA5 · T106B_RAT

  • Protein
    Transmembrane protein 106B
  • Gene
    Tmem106b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking. May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581).
In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity).
Required for proper lysosomal acidification (By similarity).
In neurons, involved in the transport of late endosomes/lysosomes (PubMed:24357581).
May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:24357581).
May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581).
In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity).
It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (By similarity).
In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity).
Required for proper lysosomal acidification (By similarity).

GO annotations

AspectTerm
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Cellular Componentlysosome
Cellular Componentplasma membrane
Molecular FunctionATPase binding
Biological Processdendrite morphogenesis
Biological Processlysosomal lumen acidification
Biological Processlysosomal protein catabolic process
Biological Processlysosomal transport
Biological Processlysosome localization
Biological Processlysosome organization
Biological Processneuron cellular homeostasis
Biological Processpositive regulation of dendrite development
Biological Processregulation of lysosome organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane protein 106B

Gene names

    • Name
      Tmem106b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q6AYA5

Proteomes

Organism-specific databases

Subcellular Location

Late endosome membrane
; Single-pass type II membrane protein
Lysosome membrane
; Single-pass type II membrane protein
Cell membrane
; Single-pass type II membrane protein
Note: Colocalizes with LAMP1 (PubMed:24357581).
A small fraction resides on the cell surface (By similarity).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-97Cytoplasmic
Transmembrane98-118Helical
Topological domain119-275Lumenal

Keywords

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain, modified residue, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00002426522-275Transmembrane protein 106B
Modified residue34Phosphoserine
Glycosylation146N-linked (GlcNAc...) asparagine
Glycosylation152N-linked (GlcNAc...) asparagine
Glycosylation165N-linked (GlcNAc...) asparagine
Glycosylation184N-linked (GlcNAc...) asparagine
Disulfide bond215↔254
Glycosylation257N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in cortical neurons (at protein level).

Gene expression databases

Interaction

Subunit

Can form homomers (By similarity).
Interacts (via N-terminus) with MAP6 (via C-terminus) (PubMed:24357581).
Interacts (via C-terminus) with the vacuolar-type ATPase subunit ATP6AP1 (By similarity).
Interacts (via N-terminus) with AP2M1 and CLTC (By similarity).
Interacts with TMEM106C (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6AYA5Map6 Q635606EBI-9316198, EBI-1638469

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-24Disordered

Sequence similarities

Belongs to the TMEM106 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    31,152
  • Last updated
    2004-09-13 v1
  • Checksum
    327903F97AE30141
MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVRNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDSQKRMIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLSNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLPSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AL12A0A8I6AL12_RATTmem106b268
Q6TUE3Q6TUE3_RATTmem106b348

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC079127
EMBL· GenBank· DDBJ
AAH79127.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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