Q6AWC2 · WWC2_HUMAN

  • Protein
    Protein WWC2
  • Gene
    WWC2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Molecular Functionkinase binding
Molecular Functionmolecular adaptor activity
Molecular Functionsignaling adaptor activity
Biological Processcell migration
Biological Processhippo signaling
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of hippo signaling
Biological Processnegative regulation of organ growth
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processregulation of DNA-templated transcription
Biological Processregulation of hippo signaling

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein WWC2
  • Alternative names
    • BH-3-only member B
    • WW domain-containing protein 2

Gene names

    • Name
      WWC2
    • Synonyms
      BOMB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6AWC2
  • Secondary accessions
    • Q32Q84
    • Q69YQ1
    • Q6AWB8
    • Q6ZSY9
    • Q6ZU09

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_036965773in dbSNP:rs11941467
Natural variantVAR_036966816in dbSNP:rs11734376
Natural variantVAR_036967904in dbSNP:rs3814422
Natural variantVAR_062108979in dbSNP:rs45470696
Natural variantVAR_0369681189in dbSNP:rs4862155

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,300 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00003094901-1192UniProtProtein WWC2
Modified residue (large scale data)7PRIDEPhosphoserine
Modified residue (large scale data)262PRIDEPhosphoserine
Modified residue (large scale data)269PRIDEPhosphoserine
Modified residue286UniProtPhosphoserine
Modified residue (large scale data)513PRIDEPhosphoserine
Modified residue (large scale data)533PRIDEPhosphothreonine
Modified residue (large scale data)851PRIDEPhosphoserine
Modified residue (large scale data)883PRIDEPhosphoserine
Modified residue (large scale data)1002PRIDEPhosphoserine
Modified residue1004UniProtPhosphothreonine
Modified residue (large scale data)1004PRIDEPhosphothreonine
Modified residue (large scale data)1006PRIDEPhosphoserine
Modified residue (large scale data)1020PRIDEPhosphoserine
Modified residue1022UniProtPhosphoserine
Modified residue (large scale data)1022PRIDEPhosphoserine
Modified residue (large scale data)1024PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms homodimers and heterodimers with WWC1 and WWC3. Interacts with DLC1 and PRKCZ. Interacts (via WW domains) with LATS1 and LATS2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q6AWC2YWHAZ P631042EBI-1055121, EBI-347088

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Domain10-43WW 1
Domain57-90WW 2
Coiled coil121-194
Coiled coil224-256
Coiled coil302-421
Region441-462Disordered
Domain698-821C2
Coiled coil859-887
Compositional bias873-887Acidic residues
Region873-895Disordered
Region911-991Disordered
Compositional bias921-935Polar residues
Region1031-1050Interaction with PRKCZ
Coiled coil1068-1144
Compositional bias1124-1141Basic and acidic residues
Region1124-1143Disordered

Sequence similarities

Belongs to the WWC family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (7)
  • Sequence status
    Complete

This entry describes 7 isoforms produced by Alternative splicing.

Q6AWC2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,192
  • Mass (Da)
    133,891
  • Last updated
    2007-11-13 v2
  • Checksum
    937D419FF18F62C0
MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV

Q6AWC2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6AWC2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q6AWC2-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 588-637: CELSSHFADISLIENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTAD → Y

Q6AWC2-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-98: Missing
    • 786-1192: VDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV → KNFTFVTAITHGVCLPLPVPMPSFA

Q6AWC2-6

  • Name
    6
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 895-895: W → WLNTYFLCCWELKDDVFTRLTVKPL

Q6AWC2-7

  • Name
    7
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-895: MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDW → MPRLRVHGACLPTKSVLFLFYHR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WET3F8WET3_HUMANWWC277
D6R9P8D6R9P8_HUMANWWC281

Sequence caution

The sequence AAH17957.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence AAI07684.1 differs from that shown. Reason: Miscellaneous discrepancy Contaminating sequence. Potential poly-A sequence.
The sequence BAB15215.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAB85032.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAD97477.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0292161-98in isoform 5
Alternative sequenceVSP_0292151-205in isoform 2
Alternative sequenceVSP_0292141-318in isoform 3
Alternative sequenceVSP_0292131-895in isoform 7
Sequence conflict108in Ref. 1; BAC86418
Sequence conflict177in Ref. 1; BAC86418
Alternative sequenceVSP_029217588-637in isoform 4
Alternative sequenceVSP_029218786-1192in isoform 5
Compositional bias873-887Acidic residues
Alternative sequenceVSP_029219895in isoform 6
Compositional bias921-935Polar residues
Sequence conflict969in Ref. 2; CAH10569
Compositional bias1124-1141Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK025682
EMBL· GenBank· DDBJ
BAB15215.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK074260
EMBL· GenBank· DDBJ
BAB85032.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK126057
EMBL· GenBank· DDBJ
BAC86418.1
EMBL· GenBank· DDBJ
mRNA
AK127061
EMBL· GenBank· DDBJ
BAC86807.1
EMBL· GenBank· DDBJ
mRNA
BX647378
EMBL· GenBank· DDBJ
CAH10569.1
EMBL· GenBank· DDBJ
mRNA
BX647704
EMBL· GenBank· DDBJ
CAH10570.1
EMBL· GenBank· DDBJ
mRNA
AL832424
EMBL· GenBank· DDBJ
CAH10641.1
EMBL· GenBank· DDBJ
mRNA
AC093844
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC099397
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC019193
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC017957
EMBL· GenBank· DDBJ
AAH17957.1
EMBL· GenBank· DDBJ
mRNA Different initiation
BC053873
EMBL· GenBank· DDBJ
AAH53873.2
EMBL· GenBank· DDBJ
mRNA
BC107683
EMBL· GenBank· DDBJ
AAI07684.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AJ566366
EMBL· GenBank· DDBJ
CAD97477.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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