Q6ALV3 · PANC_DESPS

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site30-37ATP (UniProtKB | ChEBI)
Active site37Proton donor
Binding site61(R)-pantoate (UniProtKB | ChEBI)
Binding site61beta-alanine (UniProtKB | ChEBI)
Binding site147-150ATP (UniProtKB | ChEBI)
Binding site153(R)-pantoate (UniProtKB | ChEBI)
Binding site184-187ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • Ordered locus names
      DP1943

Organism names

Accessions

  • Primary accession
    Q6ALV3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003054391-286Pantothenate synthetase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    286
  • Mass (Da)
    31,808
  • Last updated
    2004-09-13 v1
  • Checksum
    B60772556745A8F4
MKKISSRQEIREQVKKWQEQGLTVALVPTMGCFHQGHLSLIKKGREIADRLIVSLFVNPIQFGPGEDLDAYPRPYEKDSRLAEELGTDVLFCPETTEMYGPNFQTNISVTTLTADLCGAGRPGHFDGVATVVTKLFHLCQPDFAIFGEKDFQQLAMIKQLVIDLDFDLQIISCPIYREDDGLAMSSRNKYLNAEQRLKALCLSQALEVAKDYVLARSAAGKTIESDEVITKARGVIIDAGYEPEYISIVDQQTLEPSPTVQPGNVMALAVRIAERIRLIDNSALLT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR522870
EMBL· GenBank· DDBJ
CAG36672.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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