Q6ALV3 · PANC_DESPS
- ProteinPantothenate synthetase
- GenepanC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids286 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 30-37 | ATP (UniProtKB | ChEBI) | |||
Active site | 37 | Proton donor | |||
Binding site | 61 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 61 | beta-alanine (UniProtKB | ChEBI) | |||
Binding site | 147-150 | ATP (UniProtKB | ChEBI) | |||
Binding site | 153 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 184-187 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfobulbia > Desulfobulbales > Desulfocapsaceae > Desulfotalea
Accessions
- Primary accessionQ6ALV3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000305439 | 1-286 | Pantothenate synthetase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length286
- Mass (Da)31,808
- Last updated2004-09-13 v1
- ChecksumB60772556745A8F4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR522870 EMBL· GenBank· DDBJ | CAG36672.1 EMBL· GenBank· DDBJ | Genomic DNA |