Q6AHC2 · MEND_LEIXX
- Protein2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- GenemenD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids592 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
Catalytic activity
- isochorismate + 2-oxoglutarate + H+ = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway
Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.
Quinol/quinone metabolism; menaquinone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | menaquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
- EC number
- Short namesSEPHCHC synthase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Microbacteriaceae > Leifsonia
Accessions
- Primary accessionQ6AHC2
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000341764 | 1-592 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | |||
Sequence: MPDARAADEPAQRLPRTGNPATDYALALLAHLIGAGVRDIVVSPGSRSQALALAAAELERAGAVRLHVRLDERVGGFLALGIGRETGAPAAVVTTSGTATANLHPAVLEAHESGVPLIVITADRPPELRGIRSSQTTHQDGLYGVAVRLAKDVPAPSGEEEDVATAARLAVESVRAAVGAETADPGPVHLNLAFREPLSVAVPPLPVVERGALPALAGAQKLGRETVVPGIGPSTVVIAGADAGPEAEEYARSAGFPLLAEVSSGSRFGPNLVVAYRELLREPEFGGRVRRAVVFGHPTLSREVPALLLRDDVETVVVAPRGRQAYNPGRRAVIVGAVRPAVEADPRSPEARAWVGLWVSASRRLVEAAERVASPDATAPDLAKARSLDPSDALAFARMELAAVRAPITRPLLAEALWRHTWPHDRLVLGASRLIRDADRIVPGKRLRVHSNRGLAGIDGTIATAIGVALASQAVAVETGTLPGITRVLLGDLALLHDAGALLGGSGEAWPNVQVIVGNDGGGTIFDGLEVATIASPAAFDRVLYTPQRGDIAALSTAYGWAHRVVRTKGELDQALSAPPAGASVLEVPLER |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length592
- Mass (Da)61,513
- Last updated2004-09-13 v1
- ChecksumD331DF15A4332D6E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE016822 EMBL· GenBank· DDBJ | AAT88223.1 EMBL· GenBank· DDBJ | Genomic DNA |