Q6ADH0 · NB_LEIXX

Function

function

Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.

Pathway

Nitrogen metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site189Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxynitrite isomerase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxynitrite isomerase
  • EC number
  • Alternative names
    • Ferric nitrobindin (Nb(III))

Gene names

    • Ordered locus names
      Lxx18350

Organism names

Accessions

  • Primary accession
    Q6ADH0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003569101-198Peroxynitrite isomerase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif20-26GXWXGXG

Domain

Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.

Sequence similarities

Belongs to the nitrobindin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,425
  • Last updated
    2004-09-13 v1
  • Checksum
    698A0D16BE6995F6
MIEIPTDLPAELVPLSWLIGVWEGTGVLDYAIGDDHTEREFGQRIGFSHDGQNYLAYSSTAWLLDSDRTPLAAESGYWRLSRTLIEGDAGPGMLPGVGPRPFGTAQSVEALRASHGGFDIDVSIVHPNGVSELYIGRVNGPRIDLATDAVVRTAGAKEYTAATRLYGLVENHLLWAWDIAALGQELRTHASARLAKAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016822
EMBL· GenBank· DDBJ
AAT89576.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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