Q6A1A2 · PDPK2_HUMAN

  • Protein
    Putative 3-phosphoinositide-dependent protein kinase 2
  • Gene
    PDPK2P
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Uncertain
  • Annotation score
    4/5

Function

function

Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).

Caution

Could be the product of a pseudogene.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site65-67ATP (UniProtKB | ChEBI)
Binding site84ATP (UniProtKB | ChEBI)
Binding site133-135ATP (UniProtKB | ChEBI)
Binding site139ATP (UniProtKB | ChEBI)
Active site178Proton acceptor
Binding site182ATP (UniProtKB | ChEBI)
Binding site196ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular FunctionATP binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative 3-phosphoinositide-dependent protein kinase 2
  • EC number
  • Alternative names
    • 3-phosphoinositide-dependent protein kinase 2 pseudogene

Gene names

    • Name
      PDPK2P
    • Synonyms
      PDPK2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q6A1A2

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Membrane
; Peripheral membrane protein

Keywords

Disease & Variants

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003419671-396UniProtPutative 3-phosphoinositide-dependent protein kinase 2
Modified residue (large scale data)9PRIDEPhosphoserine
Modified residue (large scale data)10PRIDEPhosphothreonine
Modified residue (large scale data)37PRIDEPhosphoserine
Modified residue (large scale data)214PRIDEPhosphoserine
Modified residue (large scale data)218PRIDEPhosphothreonine

Post-translational modification

Phosphorylated on tyrosine and serine/threonine.

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues
Region1-53Disordered
Domain55-315Protein kinase
Region86-130PIF-pocket

Domain

The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    44,765
  • Last updated
    2004-09-13 v1
  • Checksum
    A0661913B473D8DF
MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMYIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNVSWPGWRARQVALGPPCTGLHARAPDPRVICSRKGRVSVPLRQACWWL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ785968
EMBL· GenBank· DDBJ
CAH05056.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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