Q6A035 · Q6A035_MOUSE
- Proteinnon-specific serine/threonine protein kinase
- GeneRock2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids777 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Publications for Q6A035
miR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson's disease models.
- AnnotationmiR-101a-3p/ROCK2 axis regulates neuronal injury in Parkinson's disease models.
- CategoryFunction
- SourceGeneRif: 19878
Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis.
- AnnotationDeletion of podocyte Rho-associated coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis.
- CategoryFunction
- SourceGeneRif: 19878
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft- versus-host disease.
- AnnotationROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.
- CategoryFunction
- SourceGeneRif: 19878
Inhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis.
- AnnotationInhibition of microRNA-34c reduces detrusor ROCK2 expression and urinary bladder inflammation in experimental cystitis.
- CategoryFunction
- SourceGeneRif: 19878
A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.
- AnnotationA 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex.
- CategoryFunction
- SourceGeneRif: 19878
[Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division].
- SourceGeneRif: 19878
- PubMed
- Europe PMC
- Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 39:701-707 ()
Mapped toalpha-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes.
- Annotationalpha-Actinin-4 recruits Shp2 into focal adhesions to potentiate ROCK2 activation in podocytes.
- CategoryFunction
- SourceGeneRif: 19878
FOXO4 alleviates hippocampal neuronal damage in epileptic mice via the miR-138-5p/ROCK2 axis.
- AnnotationFOXO4 alleviates hippocampal neuronal damage in epileptic mice via the miR-138-5p/ROCK2 axis.
- CategoriesFunction, Expression
- SourceGeneRif: 19878
Activity of ROCKII not ROCKI promotes pulmonary metastasis of melanoma cells via modulating Smad2/3-MMP9 and FAK-Src-VEGF signalling.
- AnnotationActivity of ROCKII not ROCKI promotes pulmonary metastasis of melanoma cells via modulating Smad2/3-MMP9 and FAK-Src-VEGF signalling.
- CategoryFunction
- SourceGeneRif: 19878
ROCK2-induced metabolic rewiring in diabetic podocytopathy.
- CategoriesFunction, Expression, Phenotypes & Variants
- SourceMGI: 107926
RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells: implications for Duchenne muscular dystrophy.
- AnnotationRhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells: implications for Duchenne muscular dystrophy.
- CategoryFunction
- SourceGeneRif: 19878
Conditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons.
- AnnotationConditional deletion of ROCK2 induces anxiety-like behaviors and alters dendritic spine density and morphology on CA1 pyramidal neurons.
- CategoriesFunction, Phenotypes & Variants
Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 107926
Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice.
- AnnotationExercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice.
- CategoryFunction
- SourceGeneRif: 19878
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.
- AnnotationmiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.
- CategoryFunction
0.5‑Gy X‑ray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts.
- Annotation0.5Gy Xray irradiation induces reorganization of cytoskeleton and differentiation of osteoblasts.
- CategoryFunction
- SourceGeneRif: 19878
ROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts.
- AnnotationROCK-II inhibition suppresses impaired mechanobiological responses in early estrogen deficient osteoblasts.
- CategoryFunction
- SourceGeneRif: 19878
LncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424/ROCK2 axis.
- AnnotationLncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424/ROCK2 axis.
- CategoryFunction
RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial-mesenchymal transition and proliferation in endometriosis.
- AnnotationRhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial-mesenchymal transition and proliferation in endometriosis.
- CategoryFunction
- SourceGeneRif: 19878
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
- AnnotationInhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 19878