Q69ZU8 · ANKR6_MOUSE
- ProteinAnkyrin repeat domain-containing protein 6
- GeneAnkrd6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids712 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | positive regulation of Wnt signaling pathway, planar cell polarity pathway |
Names & Taxonomy
Protein names
- Recommended nameAnkyrin repeat domain-containing protein 6
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ69ZU8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000320066 | 1-712 | Ankyrin repeat domain-containing protein 6 | |||
Sequence: MSQQDAVAALSERLLIAAYKGQTENVVQLINKGAKVAVTKHGRTPLHLAANKGHLSVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEILTALIREGCALDRQDKDGNTALHEAAWHGFSQSAKLLVKAGANVLARNKAGNTALHLACQNSHSQSTRILLLGGSRADLKNNAGDTCLHVAARYNHLSVVRLLLNAFCSVHEKNQAGDTALHVAAALNHKKVVKVLLEAGADTTIVNNAGQTPLETARYHNNPEVALLLTKAPQILRFSRGRSLRKRRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPRKDERRRKSRPEVSALSDPTPAADQQPGHQKNLHSHHHPKKKSRHRCWSPPPPHGFRAYQLYTLYRGEDGKVMQAPIKGCRCEPLINKLENQLEATVEEIRAELGSVQDKVNAKLGQMESKTQHQMCVLDKLMVERLSAERTECMNRLQQHAAAEKQEGEKRQMSLVDELKAWCMLKIQSLELRLSGESRTFRAKSTPPPSDSTPAVDQPVVAAGPGAASDSSSQVVRPKDKALNASAAHSHQQELPPSDCTGSGLRKIKAPGASRCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQPSAASSDVRDASQALELTQYFFEAVSAQMEKWYERKIEEARSQASQKAQQDEATLKEHIRSLEEELARLRTKVQK |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with AXN1, AXN2 and CSNK1E/CKI-epsilon.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q69ZU8-1 | Dvl2 Q60838 | 3 | EBI-15605686, EBI-641940 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 9-38 | ANK 1 | ||||
Sequence: ALSERLLIAAYKGQTENVVQLINKGAKVAV | ||||||
Repeat | 41-70 | ANK 2 | ||||
Sequence: HGRTPLHLAANKGHLSVVQILLKAGCDLDV | ||||||
Repeat | 74-103 | ANK 3 | ||||
Sequence: GDQTALHRATVVGNTEILTALIREGCALDR | ||||||
Repeat | 107-136 | ANK 4 | ||||
Sequence: DGNTALHEAAWHGFSQSAKLLVKAGANVLA | ||||||
Repeat | 140-169 | ANK 5 | ||||
Sequence: AGNTALHLACQNSHSQSTRILLLGGSRADL | ||||||
Repeat | 173-202 | ANK 6 | ||||
Sequence: AGDTCLHVAARYNHLSVVRLLLNAFCSVHE | ||||||
Repeat | 206-235 | ANK 7 | ||||
Sequence: AGDTALHVAAALNHKKVVKVLLEAGADTTI | ||||||
Repeat | 239-268 | ANK 8 | ||||
Sequence: AGQTPLETARYHNNPEVALLLTKAPQILRF | ||||||
Compositional bias | 277-292 | Basic and acidic residues | ||||
Sequence: RRERLKEERRAQSVPR | ||||||
Region | 277-382 | Disordered | ||||
Sequence: RRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVPQKEEARRDCPPASQEPRKDERRRKSRPEVSALSDPTPAADQQPGHQKNLHSHHHPKKKSRHRCWSPP | ||||||
Compositional bias | 294-314 | Polar residues | ||||
Sequence: EVAQSKGSVSAGDTPSSEQAV | ||||||
Compositional bias | 315-344 | Basic and acidic residues | ||||
Sequence: PQKEEARRDCPPASQEPRKDERRRKSRPEV | ||||||
Compositional bias | 363-379 | Basic residues | ||||
Sequence: NLHSHHHPKKKSRHRCW | ||||||
Coiled coil | 416-445 | |||||
Sequence: LINKLENQLEATVEEIRAELGSVQDKVNAK | ||||||
Region | 521-647 | Disordered | ||||
Sequence: RTFRAKSTPPPSDSTPAVDQPVVAAGPGAASDSSSQVVRPKDKALNASAAHSHQQELPPSDCTGSGLRKIKAPGASRCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQPSAASSDVRD | ||||||
Compositional bias | 597-647 | Polar residues | ||||
Sequence: RCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQPSAASSDVRD | ||||||
Coiled coil | 669-712 | |||||
Sequence: WYERKIEEARSQASQKAQQDEATLKEHIRSLEEELARLRTKVQK |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q69ZU8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length712
- Mass (Da)77,982
- Last updated2008-02-26 v2
- Checksum88616A71DD632AD0
Q69ZU8-2
- Name2
- Differences from canonical
- 265-299: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2ANY8 | A2ANY8_MOUSE | Ankrd6 | 648 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_031592 | 265-299 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 277-292 | Basic and acidic residues | ||||
Sequence: RRERLKEERRAQSVPR | ||||||
Compositional bias | 294-314 | Polar residues | ||||
Sequence: EVAQSKGSVSAGDTPSSEQAV | ||||||
Compositional bias | 315-344 | Basic and acidic residues | ||||
Sequence: PQKEEARRDCPPASQEPRKDERRRKSRPEV | ||||||
Compositional bias | 363-379 | Basic residues | ||||
Sequence: NLHSHHHPKKKSRHRCW | ||||||
Compositional bias | 597-647 | Polar residues | ||||
Sequence: RCDQQTGSCVNRGTQTKKSGRSGQTKHRGQQPTASSPSGQQPSAASSDVRD |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY026320 EMBL· GenBank· DDBJ | AAK15806.2 EMBL· GenBank· DDBJ | mRNA | ||
AK173070 EMBL· GenBank· DDBJ | BAD32348.1 EMBL· GenBank· DDBJ | mRNA | ||
AL831774 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466538 EMBL· GenBank· DDBJ | EDL05499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC065177 EMBL· GenBank· DDBJ | AAH65177.1 EMBL· GenBank· DDBJ | mRNA |