Q69FE3 · Q69FE3_HUMAN
- ProteinInterleukin-1 receptor-associated kinase 4
- GeneIRAK4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids460 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Molecular Function | ATP binding | |
Molecular Function | interleukin-1 receptor binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cytokine-mediated signaling pathway | |
Biological Process | innate immune response | |
Biological Process | JNK cascade | |
Biological Process | positive regulation of canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of defense response | |
Biological Process | positive regulation of smooth muscle cell proliferation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInterleukin-1 receptor-associated kinase 4
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ69FE3
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q69FE3 | MYD88 Q99836 | 5 | EBI-10249217, EBI-447677 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 186-454 | Protein kinase | ||||
Sequence: SVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLL |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length460
- Mass (Da)51,530
- Last updated2005-05-10 v1
- Checksum6C8156ADF25FF81E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY340962 EMBL· GenBank· DDBJ | AAR02358.1 EMBL· GenBank· DDBJ | mRNA | ||
AY340963 EMBL· GenBank· DDBJ | AAR02359.1 EMBL· GenBank· DDBJ | mRNA | ||
AY730682 EMBL· GenBank· DDBJ | AAX22228.1 EMBL· GenBank· DDBJ | mRNA | ||
KU178631 EMBL· GenBank· DDBJ | ALQ34089.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471111 EMBL· GenBank· DDBJ | EAW57867.1 EMBL· GenBank· DDBJ | Genomic DNA |