Q698R1 · Q698R1_CANLF
- Proteinnon-specific serine/threonine protein kinase
- GeneBRAF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids749 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | Ras protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific serine/threonine protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionQ698R1
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: QALFNGDMEPEAGAGAAASSA | ||||||
Domain | 138-210 | RBD | ||||
Sequence: PIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVL | ||||||
Domain | 217-263 | Phorbol-ester/DAG-type | ||||
Sequence: TRNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMC | ||||||
Region | 293-437 | Disordered | ||||
Sequence: TALTSGSSPSAPPSDSPGPPILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPD | ||||||
Compositional bias | 304-326 | Pro residues | ||||
Sequence: PPSDSPGPPILTSPSPSKSIPIP | ||||||
Compositional bias | 372-409 | Polar residues | ||||
Sequence: RSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRER | ||||||
Compositional bias | 410-434 | Basic and acidic residues | ||||
Sequence: KSSSSSEDRNRMKTLGRRDSSDDWE | ||||||
Domain | 440-700 | Protein kinase | ||||
Sequence: ITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELL |
Sequence similarities
Family and domain databases
Sequence
- Sequence statusFragment
- Length749
- Mass (Da)83,166
- Last updated2004-09-13 v1
- ChecksumB2EF0BD3E2ABE00D
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Q | ||||||
Compositional bias | 304-326 | Pro residues | ||||
Sequence: PPSDSPGPPILTSPSPSKSIPIP | ||||||
Compositional bias | 372-409 | Polar residues | ||||
Sequence: RSDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRER | ||||||
Compositional bias | 410-434 | Basic and acidic residues | ||||
Sequence: KSSSSSEDRNRMKTLGRRDSSDDWE |