Q68FY1 · NUP35_RAT

Function

function

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear envelope
Cellular Componentnuclear lamina
Cellular Componentnuclear membrane
Cellular Componentnuclear pore central transport channel
Cellular Componentnuclear pore nuclear basket
Molecular Functionidentical protein binding
Molecular Functionnucleic acid binding
Molecular Functionphospholipid binding
Molecular Functionstructural constituent of nuclear pore
Biological Processcellular response to leukemia inhibitory factor
Biological ProcessmRNA transport
Biological ProcessNLS-bearing protein import into nucleus
Biological Processnuclear pore organization

Keywords

Enzyme and pathway databases

    • R-RNO-159227Transport of the SLBP independent Mature mRNA
    • R-RNO-159230Transport of the SLBP Dependant Mature mRNA
    • R-RNO-159231Transport of Mature mRNA Derived from an Intronless Transcript
    • R-RNO-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
    • R-RNO-170822Regulation of Glucokinase by Glucokinase Regulatory Protein

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoporin NUP35
  • Alternative names
    • 35 kDa nucleoporin
    • Nuclear pore complex protein Nup53
    • Nucleoporin NUP53

Gene names

    • Name
      Nup35
    • Synonyms
      Nup53

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q68FY1

Proteomes

Organism-specific databases

Subcellular Location

Nucleus membrane
; Peripheral membrane protein
Note: Tightly associated with the nuclear membrane and lamina.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002342961-325Nucleoporin NUP35
Modified residue53Phosphoserine
Modified residue55Phosphoserine
Modified residue66Phosphoserine
Modified residue73Phosphoserine
Modified residue99Phosphoserine
Modified residue100Phosphoserine
Modified residue106Phosphothreonine
Modified residue121Phosphoserine
Modified residue128Phosphothreonine
Modified residue137Phosphoserine
Modified residue251Phosphoserine
Modified residue258Phosphoserine
Modified residue264Phosphothreonine
Modified residue272Phosphothreonine
Modified residue274Phosphothreonine
Modified residue278Phosphoserine
Modified residue279Phosphothreonine
Modified residue283Phosphoserine
Modified residue307Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with TMEM48/NDC1 (By similarity).
Forms a complex with NUP93, NUP155, NUP205 and lamin B. The interaction with NUP93 is direct (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-37Disordered
Region69-94Disordered
Domain169-249RRM Nup35-type

Sequence similarities

Belongs to the Nup35 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    325
  • Mass (Da)
    34,802
  • Last updated
    2004-10-11 v1
  • Checksum
    5EC3D9E5FE80B9FB
MAAFAVDPQAPTLGSEPMMLGSPTSPKPGANAQFLPGFLMGDLPAPVTPQPRSISGPSVGVMEMRSPLLAGGSPPQPVVPAHKDKSGAPPVRSIYDDISSPGLGSTPLPSRRQANISVLQSPLVGVTTPVTGQSMFSPANIGQPRKTTLSPAQLDPFYTQGDSLTSEDHLDDTWVTVFGFPQASASYILLQFAQYGNILKHVMSNTGNWMHIRYQSKLQARKALSKDGRIFGESIMIGVKPCIDKNVMENSDRGVLSSPSLAFTPPIRTLGTPTQPGSTPRVSTMRPLATAYKASTSDYQVISDRQTPKKDESLVSRAMEYMFGW

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8L2Q6A2A0A8L2Q6A2_RATNup35326
A0A8I6A1Y4A0A8I6A1Y4_RATNup35333

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC078914
EMBL· GenBank· DDBJ
AAH78914.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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