Q68FH4 · GALK2_MOUSE

  • Protein
    N-acetylgalactosamine kinase
  • Gene
    Galk2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Acts on GalNAc (By similarity).
Also acts as a galactokinase when galactose is present at high concentrations (By similarity).

Catalytic activity

Features

Showing features for binding site, site, active site.

145850100150200250300350400450
TypeIDPosition(s)Description
Binding site43alpha-D-galactose (UniProtKB | ChEBI)
Site43Transition state stabilizer
Binding site49alpha-D-galactose (UniProtKB | ChEBI)
Binding site50alpha-D-galactose (UniProtKB | ChEBI)
Binding site52alpha-D-galactose (UniProtKB | ChEBI)
Binding site143ATP (UniProtKB | ChEBI)
Binding site145ATP (UniProtKB | ChEBI)
Binding site146ATP (UniProtKB | ChEBI)
Active site190Proton acceptor
Binding site190alpha-D-galactose (UniProtKB | ChEBI)
Binding site233ATP (UniProtKB | ChEBI)
Binding site234ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiongalactokinase activity
Molecular FunctionN-acetylgalactosamine kinase activity
Biological Processgalactose metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylgalactosamine kinase
  • EC number
  • Alternative names
    • GalNAc kinase
    • Galactokinase 2

Gene names

    • Name
      Galk2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q68FH4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001846481-458N-acetylgalactosamine kinase

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the GHMP kinase family. GalK subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    50,503
  • Last updated
    2004-10-11 v1
  • Checksum
    624A5B9DE149C126
MAAEDPATRRVQVAEHPRLLKLKEMFNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHTLQLANTDPLYPDFSTTANNICIDKTKPLWHNYFLCGFKGIQEHFGLSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANSCMEMNKAATSHFNVRVMECRLAAKVLAKHKGLQWDNVLRLEEVQSKLGISLEEMLLVTEDALHPEPYSREEICRCLGISLERLRTQILTPNTQDELTFKLYQRAKHVYSEAARVLQFKQVCEDAPDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLVPADMLSSFLASVHEAYYQGNTSRLAQEKHSLFATKPGGGALVFREV

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q8BUU7Q8BUU7_MOUSEGalk2447
D6RJ57D6RJ57_MOUSEGalk236
B7ZCT3B7ZCT3_MOUSEGalk2182
B7ZCT4B7ZCT4_MOUSEGalk2129
B7ZCT5B7ZCT5_MOUSEGalk291

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC079843
EMBL· GenBank· DDBJ
AAH79843.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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