Q68FH4 · GALK2_MOUSE
- ProteinN-acetylgalactosamine kinase
- GeneGalk2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids458 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Acts on GalNAc (By similarity).
Also acts as a galactokinase when galactose is present at high concentrations (By similarity).
Also acts as a galactokinase when galactose is present at high concentrations (By similarity).
Catalytic activity
- ATP + N-acetyl-alpha-D-galactosamine = ADP + H+ + N-acetyl-alpha-D-galactosamine 1-phosphate
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 43 | alpha-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Site | 43 | Transition state stabilizer | ||||
Sequence: R | ||||||
Binding site | 49 | alpha-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 50 | alpha-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 52 | alpha-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 143 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 145 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 146 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Active site | 190 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 190 | alpha-D-galactose (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 233 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 234 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | galactokinase activity | |
Molecular Function | N-acetylgalactosamine kinase activity | |
Biological Process | galactose metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameN-acetylgalactosamine kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ68FH4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000184648 | 1-458 | N-acetylgalactosamine kinase | |||
Sequence: MAAEDPATRRVQVAEHPRLLKLKEMFNSKFGSTPKFYVRAPGRVNIIGEHIDYCGYSVIPMAVEQDMLIAVEPVKTHTLQLANTDPLYPDFSTTANNICIDKTKPLWHNYFLCGFKGIQEHFGLSKLPGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGLRLSKVELAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATNVKLPSGAVFVIANSCMEMNKAATSHFNVRVMECRLAAKVLAKHKGLQWDNVLRLEEVQSKLGISLEEMLLVTEDALHPEPYSREEICRCLGISLERLRTQILTPNTQDELTFKLYQRAKHVYSEAARVLQFKQVCEDAPDNAVQLLGELMNQSHRSCRDMYECSCPELDQLVDICRKFGAKGSRLTGAGWGGCTVSLVPADMLSSFLASVHEAYYQGNTSRLAQEKHSLFATKPGGGALVFREV |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length458
- Mass (Da)50,503
- Last updated2004-10-11 v1
- Checksum624A5B9DE149C126
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC079843 EMBL· GenBank· DDBJ | AAH79843.1 EMBL· GenBank· DDBJ | mRNA |