Q68EN5 · MACA1_HUMAN

  • Protein
    Microtubule-associated tyrosine carboxypeptidase 1
  • Gene
    MATCAP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:35482892).
Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8 (PubMed:35482892).
Recognizes adjacent tubulin dimers along the same protofilament (PubMed:35482892).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site280Zn2+ (UniProtKB | ChEBI); catalytic
Active site281Nucleophile
Binding site285Zn2+ (UniProtKB | ChEBI); catalytic
Binding site316Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Molecular Functionmetallocarboxypeptidase activity
Molecular Functiontubulin-tyrosine carboxypeptidase
Biological Processbrain development
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Microtubule-associated tyrosine carboxypeptidase 1
  • EC number
  • Alternative names
    • Microtubule-associated tyrosine carboxypeptidase

Gene names

    • Name
      MATCAP1
    • Synonyms
      KIAA0895L, MATCAP

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q68EN5
  • Secondary accessions
    • A2VCS8
    • Q8N3H9
    • Q8NAQ5
    • Q96IE5

Proteomes

Organism-specific databases

Subcellular Location

Note: Associates with microtubules.

Keywords

Disease & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis219Reduced binding to microtubules.
Mutagenesis223Reduced binding to microtubules.
Mutagenesis227Reduced binding to microtubules.
Mutagenesis280Abolished tyrosine carboxypeptidase activity.
Mutagenesis281Abolished tyrosine carboxypeptidase activity.
Mutagenesis285Abolished tyrosine carboxypeptidase activity.
Mutagenesis316Abolished tyrosine carboxypeptidase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 547 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003206191-471Microtubule-associated tyrosine carboxypeptidase 1

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q68EN5ZBTB8B Q8NAP83EBI-17494528, EBI-17494306

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-40Disordered
Region76-116Disordered

Domain

Metalloprotease with an atypical HExxxH zinc-binding motif instead of HExxH, which interrupts the active site-containing helix without affecting the integrity of the catalytic site arrangement.
The N-terminal disordered region enhances its anchoring on microtubules, while dampening processivity on the polymerized substrate.

Sequence similarities

Belongs to the peptidase MATCAP family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q68EN5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    471
  • Mass (Da)
    53,446
  • Last updated
    2004-10-11 v1
  • Checksum
    C60BC58B867DB156
MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGGTLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD

Q68EN5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 385-408: GCFSKDQVYLDGIVRILRHRQTID → ARTRCTWTASCAFCDIARPSISRC
    • 409-471: Missing

Q68EN5-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-282: MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGGTLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEI → MTVQDDMGTQDVGQGGICILVPRRAGGNVSLGEFVHVCGCVGVGWGADGWERIHVCEPLWILGCESTGGGASRCLGLGEPVCEPEFRSMRMEVSRPEPRPDGTGPGLGSQAGPRTPRPAPPPLAFPA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
I3L230I3L230_HUMANMATCAP1205

Sequence caution

The sequence AAI28540.1 differs from that shown. Reason: Erroneous initiation
The sequence CAD38862.1 differs from that shown. Reason: Erroneous translation Erroneous translation incorporating non-existent frameshift.

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0316891-282in isoform 3
Alternative sequenceVSP_031690385-408in isoform 2
Alternative sequenceVSP_031691409-471in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK092303
EMBL· GenBank· DDBJ
BAC03856.1
EMBL· GenBank· DDBJ
mRNA
AL834156
EMBL· GenBank· DDBJ
CAD38862.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
CH471092
EMBL· GenBank· DDBJ
EAW83091.1
EMBL· GenBank· DDBJ
Genomic DNA
BC007594
EMBL· GenBank· DDBJ
AAH07594.1
EMBL· GenBank· DDBJ
mRNA
BC080183
EMBL· GenBank· DDBJ
AAH80183.1
EMBL· GenBank· DDBJ
mRNA
BC128539
EMBL· GenBank· DDBJ
AAI28540.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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