MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.Lei H., Tang J., Li H., Zhang H., Lu C., Chen H., Li W., Xia Y., Tang W.View abstractCited forFUNCTION, TISSUE SPECIFICITY, INDUCTION BY MIR195CategoriesFunction, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBMC Gastroenterol. 14:123-123 (2014)Cited in1Mapped to4
Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.Guan Y., Huang D., Chen F., Gao C., Tao T., Shi H., Zhao S., Liao Z., Lo L.J.[...], Peng J.View abstractCited forFUNCTION, INTERACTION WITH CAPN3, PHOSPHORYLATION AT SER-50; SER-58 AND SER-62CategoriesFunction, PTM / Processing, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 14:e1002555-e1002555 (2016)Cited in4
Def defines a conserved nucleolar pathway that leads p53 to proteasome- independent degradation.Tao T., Shi H., Guan Y., Huang D., Chen Y., Lane D.P., Chen J., Peng J.View abstractCited forVARIANTS GLU-67 AND ASP-111, CHARACTERIZATION OF VARIANTS GLU-67 AND ASP-111, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CAPN3CategoriesFunction, Sequences, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Res. 23:620-634 (2013)Cited in310Mapped to6
Tissue and cancer-specific expression of DIEXF is epigenetically mediated by an Alu repeat.Martin B., Pappa S., Diez-Villanueva A., Mallona I., Custodio J., Barrero M.J., Peinado M.A., Jorda M.View abstractAnnotationTissue and cancer-specific expression of DIEXF is epigenetically mediated by an Alu repeat.CategoriesFunction, ExpressionSourceGeneRif: 27042PubMedEurope PMCEpigenetics 15:765-779 (2020)Mapped to5
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.Tao T., Sondalle S.B., Shi H., Zhu S., Perez-Atayde A.R., Peng J., Baserga S.J., Look A.T.View abstractAnnotationDEF is highly expressed in human neuroblastoma and its depletion in human neuroblastoma cell lines induces apoptosis.CategoryFunctionSourceGeneRif: 27042PubMedEurope PMCOncogene 36:3852-3867 (2017)Cited in1Mapped to5
Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis.Thomas S.R., Keller C.A., Szyk A., Cannon J.R., Laronde-Leblanc N.A.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res. 39:2445-2457 (2011)Cited in2Mapped to48
The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA.Meyer B., Wurm J.P., Kotter P., Leisegang M.S., Schilling V., Buchhaupt M., Held M., Bahr U., Karas M.[...], Entian K.D.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res. 39:1526-1537 (2011)Cited in1Mapped to48
The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase.Wurm J.P., Meyer B., Bahr U., Held M., Frolow O., Kotter P., Engels J.W., Heckel A., Karas M.[...], Wohnert J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res. 38:2387-2398 (2010)Cited in2Mapped to47
Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.Chen J., Ruan H., Ng S.M., Gao C., Soo H.M., Wu W., Zhang Z., Wen Z., Lane D.P., Peng J.View abstractAnnotationcharacterization of the related zebrafish proteinCategoryFunctionSourceGeneRif: 27042PubMedEurope PMCGenes Dev. 19:2900-2911 (2005)Cited in16Mapped to10