MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.Lei H., Tang J., Li H., Zhang H., Lu C., Chen H., Li W., Xia Y., Tang W.View abstractCited forFUNCTION, TISSUE SPECIFICITY, INDUCTION BY MIR195CategoriesFunction, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBMC Gastroenterol. 14:123-123 (2014)Cited in1Mapped to4
Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.Guan Y., Huang D., Chen F., Gao C., Tao T., Shi H., Zhao S., Liao Z., Lo L.J.[...], Peng J.View abstractCited forFUNCTION, INTERACTION WITH CAPN3, PHOSPHORYLATION AT SER-50; SER-58 AND SER-62CategoriesFunction, PTM / Processing, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 14:e1002555-e1002555 (2016)Cited in4
Def defines a conserved nucleolar pathway that leads p53 to proteasome- independent degradation.Tao T., Shi H., Guan Y., Huang D., Chen Y., Lane D.P., Chen J., Peng J.View abstractCited forVARIANTS GLU-67 AND ASP-111, CHARACTERIZATION OF VARIANTS GLU-67 AND ASP-111, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CAPN3CategoriesFunction, Sequences, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Res. 23:620-634 (2013)Cited in39Mapped to9
Nucleolin functions in the first step of ribosomal RNA processing.Ginisty H., Amalric F., Bouvet P.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCEMBO J 17:1476-1486 (1998)Mapped to51
Tissue and cancer-specific expression of DIEXF is epigenetically mediated by an Alu repeat.Martin B., Pappa S., Diez-Villanueva A., Mallona I., Custodio J., Barrero M.J., Peinado M.A., Jorda M.View abstractAnnotationTissue and cancer-specific expression of DIEXF is epigenetically mediated by an Alu repeat.CategoriesFunction, ExpressionSourceGeneRif: 27042PubMedEurope PMCEpigenetics 15:765-779 (2020)Mapped to5
The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.Tao T., Sondalle S.B., Shi H., Zhu S., Perez-Atayde A.R., Peng J., Baserga S.J., Look A.T.View abstractAnnotationDEF is highly expressed in human neuroblastoma and its depletion in human neuroblastoma cell lines induces apoptosis.CategoryFunctionSourceGeneRif: 27042PubMedEurope PMCOncogene 36:3852-3867 (2017)Cited in1Mapped to5
hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.Tomecki R., Labno A., Drazkowska K., Cysewski D., Dziembowski A.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCRNA Biol 12:1010-1029 (2015)Mapped to66
Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis.Yoshikawa H., Ishikawa H., Izumikawa K., Miura Y., Hayano T., Isobe T., Simpson R.J., Takahashi N.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res 43:5524-5536 (2015)Mapped to58
The roles of SSU processome components and surveillance factors in the initial processing of human ribosomal RNA.Sloan K.E., Bohnsack M.T., Schneider C., Watkins N.J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCRNA 20:540-550 (2014)Mapped to51
The first pre-rRNA-processing event occurs in a large complex: analysis by gel retardation, sedimentation, and UV cross-linking.Kass S., Sollner-Webb B.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCMol Cell Biol 10:4920-4931 (1990)Mapped to51
Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA.Preti M., O'Donohue M.F., Montel-Lehry N., Bortolin-Cavaille M.L., Choesmel V., Gleizes P.E.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res 41:4709-4723 (2013)Mapped to99+
Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing.Sloan K.E., Mattijssen S., Lebaron S., Tollervey D., Pruijn G.J., Watkins N.J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCJ Cell Biol 200:577-588 (2013)Mapped to67
NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.Freed E.F., Prieto J.L., McCann K.L., McStay B., Baserga S.J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCPLoS Genet. 8:E1002892-E1002892 (2012)Cited in6Mapped to59
The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.Morello L.G., Coltri P.P., Quaresma A.J., Simabuco F.M., Silva T.C., Singh G., Nickerson J.A., Oliveira C.C., Moore M.J., Zanchin N.I.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCPLoS ONE 6:E29174-E29174 (2011)Cited in2Mapped to62
Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis.Thomas S.R., Keller C.A., Szyk A., Cannon J.R., Laronde-Leblanc N.A.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res. 39:2445-2457 (2011)Cited in2Mapped to48
5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre- rRNA maturation and decay.Wang M., Pestov D.G.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res 39:1811-1822 (2011)Mapped to52
The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA.Meyer B., Wurm J.P., Kotter P., Leisegang M.S., Schilling V., Buchhaupt M., Held M., Bahr U., Karas M.[...], Entian K.D.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res. 39:1526-1537 (2011)Cited in1Mapped to48
Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.O'Donohue M.F., Choesmel V., Faubladier M., Fichant G., Gleizes P.E.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCJ Cell Biol 190:853-866 (2010)Mapped to62
Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals.Carron C., O'Donohue M.F., Choesmel V., Faubladier M., Gleizes P.E.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res 39:280-291 (2011)Mapped to99+
The NIP7 protein is required for accurate pre-rRNA processing in human cells.Morello L.G., Hesling C., Coltri P.P., Castilho B.A., Rimokh R., Zanchin N.I.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res 39:648-665 (2011)Mapped to63
Defects in 18 S or 28 S rRNA processing activate the p53 pathway.Holzel M., Orban M., Hochstatter J., Rohrmoser M., Harasim T., Malamoussi A., Kremmer E., Langst G., Eick D.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCJ Biol Chem 285:6364-6370 (2010)Mapped to99+
The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase.Wurm J.P., Meyer B., Bahr U., Held M., Frolow O., Kotter P., Engels J.W., Heckel A., Karas M.[...], Wohnert J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCNucleic Acids Res. 38:2387-2398 (2010)Cited in2Mapped to47
Evolutionarily conserved function of RRP36 in early cleavages of the pre- rRNA and production of the 40S ribosomal subunit.Gerus M., Bonnart C., Caizergues-Ferrer M., Henry Y., Henras A.K.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCMol. Cell. Biol. 30:1130-1144 (2010)Cited in2Mapped to51
Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen- Conradi syndrome.Armistead J., Khatkar S., Meyer B., Mark B.L., Patel N., Coghlan G., Lamont R.E., Liu S., Wiechert J.[...], Triggs-Raine B.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCAm. J. Hum. Genet. 84:728-739 (2009)Cited in1Mapped to52
A novel small-subunit processome assembly intermediate that contains the U3 snoRNP, nucleolin, RRP5, and DBP4.Turner A.J., Knox A.A., Prieto J.L., McStay B., Watkins N.J.View abstractAnnotationPathwayCategoryFunctionSourceReactome: R-HSA-6790689PubMedEurope PMCMol Cell Biol 29:3007-3017 (2009)Mapped to57