Q681I0 · ORTHL_ARATH
- ProteinE3 ubiquitin-protein ligase ORTHRUS-LIKE 1
- GeneORTHL
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids465 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | histone binding | |
Molecular Function | metal ion binding | |
Molecular Function | methyl-CpG binding | |
Molecular Function | methyl-CpNpG binding | |
Molecular Function | methyl-CpNpN binding | |
Molecular Function | ubiquitin-protein transferase activity | |
Biological Process | chromatin organization | |
Biological Process | protein ubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase ORTHRUS-LIKE 1
- EC number
- Short namesORTH-LIKE 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ681I0
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000396830 | 1-465 | E3 ubiquitin-protein ligase ORTHRUS-LIKE 1 | ||
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 31-69 | Disordered | |||
Zinc finger | 109-148 | RING-type | |||
Domain | 233-374 | YDG | |||
Domain
The RING fingers are required for ubiquitin ligase activity.
The YDG domain mediates the interaction with histone H3.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q681I0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length465
- Mass (Da)52,308
- Last updated2004-10-11 v1
- ChecksumBA501A2D3BFF8150
Q681I0-2
- Name2
- Differences from canonical
- 296-296: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B4V7 | A0A1P8B4V7_ARATH | ORTHL | 425 | ||
A0A1P8B4T9 | A0A1P8B4T9_ARATH | ORTHL | 396 | ||
A0A1P8B4U7 | A0A1P8B4U7_ARATH | ORTHL | 371 |
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_039619 | 296 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC002983 EMBL· GenBank· DDBJ | AAB81879.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AF076275 EMBL· GenBank· DDBJ | AAC28190.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161512 EMBL· GenBank· DDBJ | CAB77984.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE82661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE82662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK175637 EMBL· GenBank· DDBJ | BAD43400.1 EMBL· GenBank· DDBJ | mRNA | ||
BT022101 EMBL· GenBank· DDBJ | AAY34162.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ608275 EMBL· GenBank· DDBJ | CAE55215.1 EMBL· GenBank· DDBJ | mRNA |