Q681I0 · ORTHL_ARATH

Function

function

E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Mediates ubiquitination with the E2 ubiquitin-conjugating enzyme UBC11.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionhistone binding
Molecular Functionmetal ion binding
Molecular Functionmethyl-CpG binding
Molecular Functionmethyl-CpNpG binding
Molecular Functionmethyl-CpNpN binding
Molecular Functionubiquitin-protein transferase activity
Biological Processchromatin organization
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase ORTHRUS-LIKE 1
  • EC number
  • Short names
    ORTH-LIKE 1
  • Alternative names
    • Protein VARIANT IN METHYLATION 6
    • RING-type E3 ubiquitin transferase ORTHRUS-LIKE 1

Gene names

    • Name
      ORTHL
    • Synonyms
      ORL1, VIM6
    • ORF names
      T15F16.7, T3F12.10
    • Ordered locus names
      At4g08590

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q681I0
  • Secondary accessions
    • O22280
    • O81463
    • Q500W6
    • Q709F3

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus
Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane442-462Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003968301-465E3 ubiquitin-protein ligase ORTHRUS-LIKE 1

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, zinc finger, domain.

Type
IDPosition(s)Description
Region31-69Disordered
Zinc finger109-148RING-type
Domain233-374YDG

Domain

The RING fingers are required for ubiquitin ligase activity.
The YDG domain mediates the interaction with histone H3.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q681I0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    465
  • Mass (Da)
    52,308
  • Last updated
    2004-10-11 v1
  • Checksum
    BA501A2D3BFF8150
MTRVNQLPCDCVSTAEESLTSGTCITPTHVTSLSSPLDRSGDVDPLPVSDESGGSKADESMTDADETKKRKRILSGDCEADENNKSDGEIASLNDGVDAFTAICEDLNCSLCNQLPDRPVTILCGHNFCLKCFDKWIDQGNQICATCRSTIPDKMAANPRVNSSLVSVIRYVKVAKTAGVGTANFFPFTSNQDGPENAFRTKRAKIGEENAARIYVTVPFDHFGPIPAEHDPVRNQGVLVGESWENRVECRQWGVHLPHVSCIAGQEDYGAQSVVISGGYKDDEDHGEWFLYTGRSRGRHFANEDQEFEDLNEALRVSCEMGYPVRVVRSYKDRYSAYAPKEGVRYDGVYRIEKCWRKARFPDSFKVCRYLFVRCDNEPAPWNSDESGDRPRPLPNIPELETASDLFERKESPSWDFDEAEGRWRWMKPPPANHEQRERMKMAMTCLLLFVLIILVGSSSILYQY

Q681I0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8B4V7A0A1P8B4V7_ARATHORTHL425
A0A1P8B4T9A0A1P8B4T9_ARATHORTHL396
A0A1P8B4U7A0A1P8B4U7_ARATHORTHL371

Sequence caution

The sequence AAB81879.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence AAC28190.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB77984.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_039619296in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC002983
EMBL· GenBank· DDBJ
AAB81879.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AF076275
EMBL· GenBank· DDBJ
AAC28190.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161512
EMBL· GenBank· DDBJ
CAB77984.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE82661.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE82662.1
EMBL· GenBank· DDBJ
Genomic DNA
AK175637
EMBL· GenBank· DDBJ
BAD43400.1
EMBL· GenBank· DDBJ
mRNA
BT022101
EMBL· GenBank· DDBJ
AAY34162.1
EMBL· GenBank· DDBJ
mRNA
AJ608275
EMBL· GenBank· DDBJ
CAE55215.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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