Q67ZB6 · JMJ20_ARATH

Function

function

Histone demethylase that demethylates 'Arg-3' (H4R3me) of histone H4 with a specific activity for H4R3me2 (PubMed:22483719).
Involved in the positive regulation of gene expression (PubMed:22483719).
Together with JMJ22, positively regulates seed germination by promoting the removal of repressive histone arginine methylations (e.g. H4R3me2) at GA3ox1 and GA3ox2 to trigger gibberellic acid (GA) biosynthesis (PubMed:22483719).

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site177Fe cation (UniProtKB | ChEBI); catalytic
Binding site179Fe cation (UniProtKB | ChEBI); catalytic
Binding site255Fe cation (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular Functionhistone H3R2 demethylase activity
Molecular Functionhistone H4R3 demethylase activity
Molecular Functionmetal ion binding
Biological Processepigenetic regulation of gene expression
Biological Processgibberellic acid mediated signaling pathway
Biological Processgibberellin mediated signaling pathway
Biological Processpositive regulation of seed germination
Biological Processregulation of photomorphogenesis
Biological Processresponse to red light

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Arginine-specific demethylase JMJ20
  • EC number
  • Alternative names
    • Arginine-specific histone demethylase JMJ20
    • Jumonji domain-containing protein 20
      (AtJMJ20
      ; Protein JUMONJI 20
      )
    • [histone H4]-dimethyl-L-arginine(3) monodemethylase JMJ20

Gene names

    • Name
      JMJ20
    • ORF names
      MDC12.4
    • Ordered locus names
      At5g63080

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q67ZB6
  • Secondary accessions
    • Q680P2
    • Q9FML5

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Plants missing both JMJ20 and JMJ22 exhibit reduced seed germination efficiency during PHYB activation after red light (R)-pulse treatment due to an impaired H4R3me2 removal-dependent derepression of GA3ox1 and GA3ox2 causing lower endogenous gibberellic acid (GA) biosynthesis.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 46 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004561901-462Arginine-specific demethylase JMJ20

Proteomic databases

Expression

Tissue specificity

Mostly expressed in leaves, and, to a lower extent, in inflorescences, roots, siliques and stems.

Induction

Repressed by the zinc-finger protein SOMNUS when PHYB is inactive in far-red (FR) conditions, but derepressed upon PHYB activation by red light (R).

Developmental stage

In far-red light (FR)-treated seeds, present in the whole embryo (PubMed:22483719).
Accumulates upon red light (R) (PubMed:22483719).

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain115-287JmjC

Sequence similarities

Belongs to the JARID1 histone demethylase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    462
  • Mass (Da)
    54,358
  • Last updated
    2004-10-11 v1
  • Checksum
    D6D79E33AE4821B2
MGIQIIGQIERINGKELSYGDFAERYLAKNQPVVISDLTEDWRAREDWVSENGNPNLHVFATHFGKSRVQVADCDTREFTDQKRLEMSVTEFVEQWTNKDSIEESVLYLKDWHFVKEYPDYTAYQTPPLFSDDWLNVYLDNYQMHEDRDSFQKYDQISCSDYRFVYMGGKGSWTPLHADVFRSYSWSANVCGKKRWLFLPPPQSHLVYDRYMKNCVYDIFEEVNETKFPGFKKTTWLECIQEPGEIIFVPSGWHHQVYNLEDTISINHNWLNAYNLSWVWDLLWKDYKDTEESIEDIRDICDDFEAICQRNLAANTGMNLNDFFLFMSRFSLGNMVLLQSYSDKHKNLNSCSLAMAQNLLMNLSTILKVMMKMISAGGVTAEEVYLDLRETLEDPQFLRFVRDMGRTYARIHMEEEDQFLSSKELLQKLSGLAGPNMQICSPKDLVEMINHHNTFSSQIYFI

Sequence caution

The sequence BAB10550.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB008265
EMBL· GenBank· DDBJ
BAB10550.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED97697.1
EMBL· GenBank· DDBJ
Genomic DNA
AK175825
EMBL· GenBank· DDBJ
BAD43588.1
EMBL· GenBank· DDBJ
mRNA
AK176202
EMBL· GenBank· DDBJ
BAD43965.1
EMBL· GenBank· DDBJ
mRNA
BT023460
EMBL· GenBank· DDBJ
AAY56451.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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