Q67MI1 · Q67MI1_SYMTH

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Molecular Functionserine-type D-Ala-D-Ala carboxypeptidase activity
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1A
  • EC number

Gene names

    • Ordered locus names
      STH2127

Organism names

Accessions

  • Primary accession
    Q67MI1

Proteomes

Subcellular Location

Cell membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane28-55Helical

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain79-251Glycosyl transferase family 51
Domain344-597Penicillin-binding protein transpeptidase
Compositional bias651-671Pro residues
Region651-689Disordered
Region770-857Disordered
Compositional bias828-844Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    857
  • Mass (Da)
    90,870
  • Last updated
    2004-10-11 v1
  • MD5 Checksum
    F3BA6A8B7B0D77E7A774C396942DD490
MQFNVKEVEPMPRASNARQRRPRKTRLWLRRAVQGVTLLVAAWLLYCAGSAVYLFSSLPAAGLHPGRPSMVYAFDGSEIGPLTGDVYRVPVDLGELPEYLPRAFVASEDRRFYQHPGVDLRGIARALLTNLRARSIIEGGSTITQQVVKNTFLTPRQTLTRKVQEAVLALLLETRYEKDEILSLYLNQLYMGHGTYGVGAAAQIYFNKDARDLTLGEAATLAGIAPAPESFSPLRDPEAARERRDLVLDRMVAAGYLTPEEADAEKARPLNVVQGELELNNPFPWYMDEVRAELLERYGLDPQVVALMGLEIHTGLDPAMQQAAEERLAARIFPAHTPDGVEAAFAAVDPRSGEVRALVGGREYPPGGGLNRATRGRISPGSTLKPVLVYAPAIEYEGLTPDSIVVDEPLDINGWQPQNWDFRFRGEVTLREAARLSLNIPAVQLLDRVGVERAKAFAERLGIRFAEADRDLTLALGAMADGVSPLEMAGAYQAFANGGTYREPHTITRVMATGAELKGRSAAVRRAMRPETAHAVTDILQTVVTQGTGTGALIGRPMAGKTGSVELPPDPAFEGLSGNSAAWFVGYTPDVVACVWVGYDRVDPEHYLPPDVNGSTYPTLLWRQVVGAALAGRPVLDFPGPGGGPPVVVQMPAPPAGPEEPAGPAEPTPPALPRIAGLTAAPGPQPGSVNLAWQAEGGDVPTENLRFLVLRGTDADVPADDAHTLATVASSPYLDVLTQPGTYYYRVAAVDAATGTVGEPSAPVAVEVTLEEPGGQGPGDGAEPGDEREPDDGGGPGDDGGPALPGEDGEPVGGGPADPGNGGRPAEGEPDAPERDDGHPAQGEPDEPEGGSPPAEG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias651-671Pro residues
Compositional bias828-844Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP006840
EMBL· GenBank· DDBJ
BAD41112.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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