Q675Q9 · Q675Q9_OIKDI

Function

function

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site57Phosphoserine intermediate
Binding site57Mg2+ (UniProtKB | ChEBI); via phosphate group
Binding site262Mg2+ (UniProtKB | ChEBI)
Binding site264Mg2+ (UniProtKB | ChEBI)
Binding site266Mg2+ (UniProtKB | ChEBI)
Binding site353-355substrate
Binding site469-473substrate
Binding site478substrate

GO annotations

AspectTerm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoacetylglucosamine mutase activity
Biological Processcarbohydrate metabolic process
Biological ProcessUDP-N-acetylglucosamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoacetylglucosamine mutase
  • EC number
  • Short names
    PAGM
  • Alternative names
    • Acetylglucosamine phosphomutase
    • N-acetylglucosamine-phosphate mutase

Gene names

    • ORF names
      006-14

Organism names

Accessions

  • Primary accession
    Q675Q9

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-78Alpha-D-phosphohexomutase alpha/beta/alpha
Domain91-161Alpha-D-phosphohexomutase alpha/beta/alpha
Domain194-269Phosphoacetylglucosamine mutase AMG1
Domain282-408Phosphoacetylglucosamine mutase AMG1
Domain453-496Alpha-D-phosphohexomutase C-terminal

Sequence similarities

Belongs to the phosphohexose mutase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    513
  • Mass (Da)
    55,065
  • Last updated
    2004-10-11 v1
  • Checksum
    A23E87E861023A34
MSFERAPGTKQVKYGTAGFRGPADDGQMGFIVKRSGITAALRSRKLGKATGLMITASHNPVRDNGVKVTEPLGEMLVPNWEGLATDLTNADDLNAEIAKVIKSEEISSSSEGLVILGRDTRPSSAELSFAATEGIIQAQSRSLNLGVVTTPQLHYLTYKINKGTPVFNLNLDLYYSDFTNAFLEITKNSGNLGSVEVDCANGVGLLAGAQFAKRLESKVNIKLTNAGDGLLNHDCGADFVKTGQRAPVGSEMKEGVRYCSVDGDADRLVYYFLRAGKFFLLDGDRIACLIATYLQKRLGKDSSVNFGVVQTAYANGASTNYLSALGIKTVCTKTGVKHLHHAALDFDIGVYFEANGHGTVLFNDSAIAKLEKEGHSEILALAKLVNQTVGDAFSDMLAVEAVLYLLNWGIEDWAAMYSDYPNRLMKVKIANRADIQVTNAERTCIAPAGLQDKLDSLVATVANGRSFVRASGTEDVVRVYAEANTAENCDKLSIAVANLVFDMADGQGDKPSL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY449462
EMBL· GenBank· DDBJ
AAS21455.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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