Q675Q9 · Q675Q9_OIKDI
- ProteinPhosphoacetylglucosamine mutase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.
Catalytic activity
- N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 57 | Phosphoserine intermediate | |||
Binding site | 57 | Mg2+ (UniProtKB | ChEBI); via phosphate group | |||
Binding site | 262 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 264 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 266 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 353-355 | substrate | |||
Binding site | 469-473 | substrate | |||
Binding site | 478 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | magnesium ion binding | |
Molecular Function | phosphoacetylglucosamine mutase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | UDP-N-acetylglucosamine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoacetylglucosamine mutase
- EC number
- Short namesPAGM
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Tunicata > Appendicularia > Copelata > Oikopleuridae > Oikopleura
Accessions
- Primary accessionQ675Q9
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 43-78 | Alpha-D-phosphohexomutase alpha/beta/alpha | |||
Domain | 91-161 | Alpha-D-phosphohexomutase alpha/beta/alpha | |||
Domain | 194-269 | Phosphoacetylglucosamine mutase AMG1 | |||
Domain | 282-408 | Phosphoacetylglucosamine mutase AMG1 | |||
Domain | 453-496 | Alpha-D-phosphohexomutase C-terminal | |||
Sequence similarities
Belongs to the phosphohexose mutase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)55,065
- Last updated2004-10-11 v1
- ChecksumA23E87E861023A34
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY449462 EMBL· GenBank· DDBJ | AAS21455.1 EMBL· GenBank· DDBJ | Genomic DNA |