Q67477 · 3BHS_FOWPN
- Protein3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids370 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta5-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).
Catalytic activity
- a 3beta-hydroxy-Delta5-steroid + NAD+ = a 3-oxo-Delta5-steroid + H+ + NADH
Pathway
Lipid metabolism; steroid biosynthesis.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity | |
Molecular Function | steroid delta-isomerase activity | |
Biological Process | steroid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
- Short names3-beta-HSD
Including 2 domains:
- Recommended name3-beta-hydroxy-Delta(5)-steroid dehydrogenase
- EC number
- Alternative names
- Recommended nameSteroid Delta-isomerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Pokkesviricetes > Chitovirales > Poxviridae > Chordopoxvirinae > Avipoxvirus > Fowlpox virus
- Virus hosts
Accessions
- Primary accessionQ67477
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000087797 | 1-370 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase | |||
Sequence: MRTLVYVVTGGCGFLGRHIINNLILFESSLKEVRVYDIRIDQWLLDLVEKCNIIKIVPVIGDVRNKSTLDEALRSADVVIHIASINDVAGKFTNDSIMDVNINGTKNVVDSCLYNGVRVLVYTSSYSAVGPNFLGDAMIRGNENTYYQSNHKEAYPLSKQLSEKYILEANGTMSNIGLRLCTCALRPLGVFGEYCPVLETLYRRSYKSRKMYKYADDKVFHSRVYAGNVAWMHILAARNMIENGQHSPLCNNVYYCYDTSPTEHYHDFNMHFFNQLGMDLRNTCLPLWCLRFIANINKGLRVLLSPICSYTPLLNPYTLIKECTTFTIETDKAFKDFGYVPLYTWEESRSKTQLWIRELEAKSSSQKPKS |
Sequence
- Sequence statusComplete
- Length370
- Mass (Da)42,349
- Last updated2001-08-29 v2
- Checksum730FE72BA84FA681
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 38-43 | in Ref. 1; CAA82802 | ||||
Sequence: IRIDQW → LDRPM | ||||||
Sequence conflict | 251 | in Ref. 1; CAA82802 | ||||
Sequence: N → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z29716 EMBL· GenBank· DDBJ | CAA82802.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF198100 EMBL· GenBank· DDBJ | AAF44390.1 EMBL· GenBank· DDBJ | Genomic DNA |