Q66K14 · TBC9B_HUMAN

  • Protein
    TBC1 domain family member 9B
  • Gene
    TBC1D9B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May act as a GTPase-activating protein for Rab family protein(s).

Features

Showing features for site.

112501002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Site555Arginine finger
Site594Glutamine finger

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular FunctionGTPase activator activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TBC1 domain family member 9B

Gene names

    • Name
      TBC1D9B
    • Synonyms
      KIAA0676

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q66K14
  • Secondary accessions
    • D3DWQ5
    • D3DWQ6
    • O75163
    • Q53EY0
    • Q6MZI2
    • Q96H49

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane668-688Helical

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_032440240in dbSNP:rs1057078
Natural variantVAR_032441706in dbSNP:rs10037618
Natural variantVAR_0361961086in a breast cancer sample; somatic mutation
Natural variantVAR_0324421119in dbSNP:rs30386

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,422 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00002885011-1250UniProtTBC1 domain family member 9B
Modified residue (large scale data)363PRIDEPhosphoserine
Modified residue397UniProtPhosphothreonine
Modified residue (large scale data)397PRIDEPhosphothreonine
Modified residue (large scale data)407PRIDEPhosphoserine
Modified residue411UniProtPhosphoserine
Modified residue (large scale data)411PRIDEPhosphoserine
Modified residue (large scale data)427PRIDEPhosphoserine
Modified residue432UniProtPhosphoserine
Modified residue (large scale data)432PRIDEPhosphoserine
Modified residue435UniProtPhosphoserine
Modified residue (large scale data)435PRIDEPhosphoserine
Modified residue (large scale data)439PRIDEPhosphoserine
Modified residue (large scale data)442PRIDEPhosphoserine
Modified residue463UniProtPhosphoserine
Modified residue (large scale data)463PRIDEPhosphoserine
Modified residue (large scale data)547PRIDEPhosphoserine
Modified residue (large scale data)741PRIDEPhosphoserine
Modified residue (large scale data)752PRIDEPhosphoserine
Modified residue (large scale data)994PRIDEPhosphoserine
Modified residue (large scale data)995PRIDEPhosphoserine
Modified residue (large scale data)1138PRIDEPhosphoserine
Modified residue (large scale data)1144PRIDEPhosphoserine
Modified residue (large scale data)1238PRIDEPhosphoserine
Modified residue (large scale data)1239PRIDEPhosphothreonine
Modified residue1241UniProtPhosphoserine
Modified residue (large scale data)1241PRIDEPhosphoserine
Modified residue (large scale data)1249PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q66K14-2GABARAPL2 P605203EBI-10217736, EBI-720116
BINARY Q66K14-2L3MBTL2 Q969R53EBI-10217736, EBI-739909

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain142-209GRAM 1
Domain288-356GRAM 2
Region397-443Disordered
Domain508-695Rab-GAP TBC
Domain879-914EF-hand
Region974-999Disordered
Compositional bias980-999Basic and acidic residues
Compositional bias1069-1092Basic and acidic residues
Region1069-1093Disordered
Region1128-1157Disordered
Compositional bias1129-1143Polar residues

Domain

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q66K14-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,250
  • Mass (Da)
    140,525
  • Last updated
    2010-05-18 v3
  • Checksum
    35D9E4914B1D8311
MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG

Q66K14-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YB58H0YB58_HUMANTBC1D9B65
H0YB08H0YB08_HUMANTBC1D9B166
G3V133G3V133_HUMANTBC1D9B409
E5RIN2E5RIN2_HUMANTBC1D9B100
A0AAG2TEQ7A0AAG2TEQ7_HUMANTBC1D9B100

Sequence caution

The sequence AAH08919.3 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict893in Ref. 5; BAD97229
Alternative sequenceVSP_025699955-971in isoform 2
Compositional bias980-999Basic and acidic residues
Compositional bias1069-1092Basic and acidic residues
Compositional bias1129-1143Polar residues
Sequence conflict1231in Ref. 6; CAE46050

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB014576
EMBL· GenBank· DDBJ
BAA31651.1
EMBL· GenBank· DDBJ
mRNA
AC008393
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC010285
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471165
EMBL· GenBank· DDBJ
EAW53780.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471165
EMBL· GenBank· DDBJ
EAW53782.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471165
EMBL· GenBank· DDBJ
EAW53777.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471165
EMBL· GenBank· DDBJ
EAW53779.1
EMBL· GenBank· DDBJ
Genomic DNA
BC008919
EMBL· GenBank· DDBJ
AAH08919.3
EMBL· GenBank· DDBJ
mRNA Different initiation
BC080659
EMBL· GenBank· DDBJ
AAH80659.1
EMBL· GenBank· DDBJ
mRNA
AK223509
EMBL· GenBank· DDBJ
BAD97229.1
EMBL· GenBank· DDBJ
mRNA
BX641107
EMBL· GenBank· DDBJ
CAE46050.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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