Q66JJ0 · FOXO1_XENTR

Function

function

Transcription factor that regulates metabolic homeostasis in response to oxidative stress. Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Acts synergistically with atf4 to suppress osteocalcin/bglap activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of runx2, an upstream activator of osteocalcin/bglap. May act as a positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (By similarity).

Features

Showing features for dna binding.

162650100150200250300350400450500550600
TypeIDPosition(s)Description
DNA binding144-238Fork-head

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Functionsequence-specific DNA binding
Biological Processcellular response to cold
Biological Processcellular response to hyperoxia
Biological Processcellular response to starvation
Biological Processenergy homeostasis
Biological Processfat cell differentiation
Biological Processintracellular glucose homeostasis
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of insulin secretion
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of autophagy
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of gluconeogenesis
Biological Processpositive regulation of protein catabolic process
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein acetylation
Biological Processresponse to fatty acid
Biological Processtemperature homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Forkhead box protein O1
  • Short names
    FoxO1
  • Alternative names
    • FoxO1A

Gene names

    • Name
      foxo1
    • Synonyms
      foxo1a

Organism names

Accessions

  • Primary accession
    Q66JJ0

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Shuttles between the cytoplasm and nucleus.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002709871-626Forkhead box protein O1

Post-translational modification

Phosphorylated by AKT1; insulin-induced.
IGF1 rapidly induces phosphorylation of Thr-28, Ser-240 and Ser-303. Phosphorylation of Ser-240 decreases DNA-binding activity and promotes the phosphorylation of Thr-28, and Ser-303, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser-313 is independent of IGF1 and leads to reduced function (By similarity).

Keywords

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-15Pro residues
Region1-57Disordered
Compositional bias33-51Polar residues
Region90-142Disordered
Compositional bias94-142Polar residues
Region218-319Disordered
Compositional bias257-313Polar residues
Region484-519Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    626
  • Mass (Da)
    67,806
  • Last updated
    2004-10-11 v1
  • Checksum
    210E6A483347B9C1
MAEAPLPPPPGVEVDPDFEPFSRPRSCTWPLPRPEFNPSSSANSSPAPSLQPEPAAGNVDFLSNLSLLEESEDFDPAEALGVCGDFPCQDIRQLQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRNAWGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRVQNEGTGKSSWWILNPEGGKNGKSPRRRAASMDNNSKFAKSRGRAAKKKATMQSSQDGSSDSPGSQFSKWPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLSPIMPEQDDLGDADVHNLVYPPSATKLTSTLPSLSEMGNSENMENLLDNLNLLSPNTSTQSSPASMMQQSGYLFTSPNTSLGSPNSEYRKYSYAQTGMNPVSQMPMQTVPENKSGYRAVGQYPVPAGLLKELLTSDSPPHNDILTPVDSAVSQANSRVLAQNSLMAPSSVMPTYGSQPTHNKMSSHPHSHQPPPNHPSVNGRTMTHNSGINRLSTVKTSVQVPMPQPIQMTSMGSYPVNSCNGYGRVGIVSIHQEILPSDLDDMFIESLDCDMESIIRNDLMEDGEADFNFDSILPNQSFPHSVTTTTHSWVSG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8J1J1N2A0A8J1J1N2_XENTRfoxo1626

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-15Pro residues
Compositional bias33-51Polar residues
Compositional bias94-142Polar residues
Compositional bias257-313Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC080894
EMBL· GenBank· DDBJ
AAH80894.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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