Q66JJ0 · FOXO1_XENTR
- ProteinForkhead box protein O1
- Genefoxo1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids626 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Transcription factor that regulates metabolic homeostasis in response to oxidative stress. Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of sox9, which induces chondrogenic commitment and suppresses fatty acid oxidation. Acts synergistically with atf4 to suppress osteocalcin/bglap activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of runx2, an upstream activator of osteocalcin/bglap. May act as a positive regulator of apoptosis in cardiac smooth muscle cells as a result of its transcriptional activation of pro-apoptotic genes (By similarity).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 144-238 | Fork-head | ||||
Sequence: WGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRVQNEGTGKSSWWILNPEGGKNGKSPRRRA |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameForkhead box protein O1
- Short namesFoxO1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionQ66JJ0
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000270987 | 1-626 | Forkhead box protein O1 | |||
Sequence: MAEAPLPPPPGVEVDPDFEPFSRPRSCTWPLPRPEFNPSSSANSSPAPSLQPEPAAGNVDFLSNLSLLEESEDFDPAEALGVCGDFPCQDIRQLQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRNAWGNLSYADLISQAIESSPEKRLTLSQIYDWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFVRVQNEGTGKSSWWILNPEGGKNGKSPRRRAASMDNNSKFAKSRGRAAKKKATMQSSQDGSSDSPGSQFSKWPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLSPIMPEQDDLGDADVHNLVYPPSATKLTSTLPSLSEMGNSENMENLLDNLNLLSPNTSTQSSPASMMQQSGYLFTSPNTSLGSPNSEYRKYSYAQTGMNPVSQMPMQTVPENKSGYRAVGQYPVPAGLLKELLTSDSPPHNDILTPVDSAVSQANSRVLAQNSLMAPSSVMPTYGSQPTHNKMSSHPHSHQPPPNHPSVNGRTMTHNSGINRLSTVKTSVQVPMPQPIQMTSMGSYPVNSCNGYGRVGIVSIHQEILPSDLDDMFIESLDCDMESIIRNDLMEDGEADFNFDSILPNQSFPHSVTTTTHSWVSG |
Post-translational modification
Phosphorylated by AKT1; insulin-induced.
IGF1 rapidly induces phosphorylation of Thr-28, Ser-240 and Ser-303. Phosphorylation of Ser-240 decreases DNA-binding activity and promotes the phosphorylation of Thr-28, and Ser-303, which leads to nuclear exclusion and loss of function. Phosphorylation of Ser-313 is independent of IGF1 and leads to reduced function (By similarity).
Keywords
- PTM
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Pro residues | ||||
Sequence: MAEAPLPPPPGVEVD | ||||||
Region | 1-57 | Disordered | ||||
Sequence: MAEAPLPPPPGVEVDPDFEPFSRPRSCTWPLPRPEFNPSSSANSSPAPSLQPEPAAG | ||||||
Compositional bias | 33-51 | Polar residues | ||||
Sequence: RPEFNPSSSANSSPAPSLQ | ||||||
Region | 90-142 | Disordered | ||||
Sequence: DIRQLQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRN | ||||||
Compositional bias | 94-142 | Polar residues | ||||
Sequence: LQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRN | ||||||
Region | 218-319 | Disordered | ||||
Sequence: SSWWILNPEGGKNGKSPRRRAASMDNNSKFAKSRGRAAKKKATMQSSQDGSSDSPGSQFSKWPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLSPIMPEQ | ||||||
Compositional bias | 257-313 | Polar residues | ||||
Sequence: KKATMQSSQDGSSDSPGSQFSKWPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLS | ||||||
Region | 484-519 | Disordered | ||||
Sequence: PTYGSQPTHNKMSSHPHSHQPPPNHPSVNGRTMTHN |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length626
- Mass (Da)67,806
- Last updated2004-10-11 v1
- Checksum210E6A483347B9C1
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8J1J1N2 | A0A8J1J1N2_XENTR | foxo1 | 626 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Pro residues | ||||
Sequence: MAEAPLPPPPGVEVD | ||||||
Compositional bias | 33-51 | Polar residues | ||||
Sequence: RPEFNPSSSANSSPAPSLQ | ||||||
Compositional bias | 94-142 | Polar residues | ||||
Sequence: LQPPVPQQHPQQQAGTLCAPSVPSALSPASSPSPLGAQQPRKSSSSRRN | ||||||
Compositional bias | 257-313 | Polar residues | ||||
Sequence: KKATMQSSQDGSSDSPGSQFSKWPGSPSSQSNDDFEAWSTFRPRTSSNASTISGRLS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC080894 EMBL· GenBank· DDBJ | AAH80894.1 EMBL· GenBank· DDBJ | mRNA |