Q66IE4 · T237B_DANRE

Function

function

Component of the transition zone in primary cilia. Required for ciliogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentciliary transition zone
Cellular Componentmembrane
Biological Processcilium assembly
Biological Processconvergent extension involved in gastrulation
Biological Processregulation of Wnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane protein 237B
  • Alternative names
    • Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog B

Gene names

    • Name
      tmem237b
    • Synonyms
      als2cr4b
    • ORF names
      zgc:101660

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q66IE4

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Note: Localizes to the transition zone.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane233-253Helical
Transmembrane274-294Helical
Transmembrane312-332Helical
Transmembrane360-380Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Fishes lacking both tmem237a and tmem237b display defects in midsomitic embryos, including shortening of the anterior-posterior axis and small anterior structures, kinking of the notochord, and broadening and thinning of the somite.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004158321-413Transmembrane protein 237B

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-162Disordered
Compositional bias41-59Basic and acidic residues

Sequence similarities

Belongs to the TMEM237 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    413
  • Mass (Da)
    45,969
  • Last updated
    2004-10-11 v1
  • Checksum
    E68806A1760B24AD
MDPEAKVSSSRRRDLPPIPQGQRRTPRALPSMPSQDTAEEMPAPKSRKKKAKRDAESVDEPDDGGMEMGGLASRRQSECPEPLTPEPLDNPPQRRKKKKKAQAIDAEGDQTDLVSNGDTLDQNTDEEVTRKPKKRKVKPKVTETQSNNELDVEDDDVITDPQSPIPQHSLFSAPQGPSQPVGKVFVEKSRRFQAADRVEQWKPSGPIEQSIMDIRSMWTTRDVSMRVHSGFRVIGLFSHGFLAGYAVWNIIVVYVLAGDQMSSLSNLLQQFHTLAYPAQSLLYLLLALSTVSAFDRVNLAKAPAAMRSLLRLSPVALASVFYFSALVLSLSQQMTSDRINLYKYSSYNTTLWPPGSESSILYPWITVNLVVSLLVGLAWILMSTSPDIDNTEAFLMSMEMEYPNSEEKGNVTA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M3AT44A0A8M3AT44_DANREtmem237b414

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias41-59Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU570787
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC081384
EMBL· GenBank· DDBJ
AAH81384.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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