Q66IA6 · LYPD6_DANRE

Function

function

Acts as an important regulator of embryogenesis through its enhancement of Wnt/beta-catenin signaling. Positively regulates Wnt/beta-catenin signaling by ensuring phosphorylation of lrp6 specifically in plasma membrane rafts and its subsequent internalization into signaling-competent vesicles. Essential for the wnt8-mediated patterning of the mesoderm and neuroectoderm during gastrulation (PubMed:23987510).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionacetylcholine receptor inhibitor activity
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processregulation of canonical Wnt signaling pathway
Biological Processregulation of Wnt signaling pathway
Biological ProcessSpemann organizer formation

Names & Taxonomy

Protein names

  • Recommended name
    Ly6/PLAUR domain-containing protein 6

Gene names

    • Name
      lypd6

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q66IA6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation, propeptide.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500897095223-149Ly6/PLAUR domain-containing protein 6
Disulfide bond49↔77
Disulfide bond52↔61
Disulfide bond70↔96
Disulfide bond102↔121
Disulfide bond107↔118
Disulfide bond122↔127
Glycosylation134N-linked (GlcNAc...) asparagine
Glycosylation147N-linked (GlcNAc...) asparagine
Lipidation149GPI-anchor amidated serine
PropeptidePRO_0000457044150-174Removed in mature form

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Initially detected in mesendodermal cells at late blastula stages. During gastrulation, expressed in a broad marginal domain and becomes excluded from the ventral animal pole at late gastrula stages. During segmentation, initially exclusively detected in the somitic mesoderm but later also in the otic and optic vesicles. During organogenesis, expression is largely down-regulated in the somites but maintained in the otic vesicles and the retina.

Gene expression databases

Interaction

Subunit

Interacts with fzd8 and lrp6 (PubMed:23987510).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-141UPAR/Ly6

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    174
  • Mass (Da)
    19,585
  • Last updated
    2004-10-11 v1
  • Checksum
    15D60A11C09D57C3
MEPWPLMAWGLMLTAITGWIKAVQSRDFTEKDIIFLHPSTTPYPGGFKCFTCEDAPDNYECNRWAPDLYCPRESRYCYTHHKMSWDGNTVSVTKRCVPLEDCLQTGCSDIDHEGNRVCTACCEGNICNLPLPRNETDAIFSTTSPINRSAQSTQTLPLLLLSVSITSLMLHSIN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9Q4J3A0A8M9Q4J3_DANRElypd6174

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR394542
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC081426
EMBL· GenBank· DDBJ
AAH81426.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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