Q66HX1 · Q66HX1_DANRE

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for active site, binding site.

147550100150200250300350400450
TypeIDPosition(s)Description
Active site211Nucleophile
Binding site211Mg2+ (UniProtKB | ChEBI)
Active site213Proton donor
Binding site213Mg2+ (UniProtKB | ChEBI)
Binding site439Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionprotein tyrosine phosphatase activity
Biological Processcell differentiation
Biological Processinner ear development
Biological Processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processpositive regulation of DNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Eyes absent homolog
  • EC number

Gene names

    • Name
      eya2
    • Synonyms
      zgc:92279

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q66HX1
  • Secondary accessions
    • A0A8M1N288

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region37-56Disordered
Compositional bias143-169Polar residues
Region143-198Disordered
Compositional bias177-198Basic and acidic residues

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. EYA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    475
  • Mass (Da)
    52,310
  • Last updated
    2004-10-11 v1
  • Checksum
    52FDBF60801ACBE3
MAAYGQTQYSPALQPAGPYTPYTHHTQGYSMTSYNIKTEDGLSHSPGQSSLLGYTPNFSGTPPGQTLYSYSHGGSISSGIFQGANSITGSTPFSPAQQDFSTYSSYSQSQYSPYYNTHYNSPYITASNITPSAITTAIPYQHTDHPAVSTNHSPESHTAEYQAPTSPPTPGKDQDGAPPRRSADGKLRGRKRASDPVPPLDSDIERVFVWDLDETIIIFHSLLTGTFSTRFGKDSGKAVSLGLWMEEMIFNLADSRLFFNDLEECDQVHIDDVASDDNGQDLSTYNFGTDGFQTPAGGGSLCLGSGVHGGVDWMRKLAFRYRRVKEIYNTYKNNVGGLLGSPKREEWLQLRREMEVLTDLWLTQALKALALINSRPNCVNVLVTTTQLIPALSKVLLYGLGGAFPIENIYSATKTGKESCFERVTQRFGRRAVYVVVGDGIEEETVAKKKNMPFWRVTCRADLEALSHALELDYL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias143-169Polar residues
Compositional bias177-198Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU468922
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CU571175
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CU856349
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC081636
EMBL· GenBank· DDBJ
AAH81636.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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