Q66C31 · ASSY_YERPS
- ProteinArgininosuccinate synthase
- GeneargG
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids455 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H+
Pathway
Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17-25 | ATP (UniProtKB | ChEBI) | |||
Binding site | 43 | ATP (UniProtKB | ChEBI) | |||
Binding site | 99 | L-citrulline (UniProtKB | ChEBI) | |||
Binding site | 129 | ATP (UniProtKB | ChEBI) | |||
Binding site | 131 | ATP (UniProtKB | ChEBI) | |||
Binding site | 131 | L-aspartate (UniProtKB | ChEBI) | |||
Binding site | 135 | L-aspartate (UniProtKB | ChEBI) | |||
Binding site | 135 | L-citrulline (UniProtKB | ChEBI) | |||
Binding site | 136 | ATP (UniProtKB | ChEBI) | |||
Binding site | 136 | L-aspartate (UniProtKB | ChEBI) | |||
Binding site | 139 | L-citrulline (UniProtKB | ChEBI) | |||
Binding site | 192 | L-citrulline (UniProtKB | ChEBI) | |||
Binding site | 194 | ATP (UniProtKB | ChEBI) | |||
Binding site | 201 | L-citrulline (UniProtKB | ChEBI) | |||
Binding site | 203 | L-citrulline (UniProtKB | ChEBI) | |||
Binding site | 280 | L-citrulline (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | argininosuccinate synthase activity | |
Molecular Function | ATP binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | arginine biosynthetic process | |
Biological Process | argininosuccinate metabolic process | |
Biological Process | urea cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArgininosuccinate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia
Accessions
- Primary accessionQ66C31
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000025448 | 1-455 | Argininosuccinate synthase | ||
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 434-449 | Polar residues | |||
Region | 434-455 | Disordered | |||
Sequence similarities
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length455
- Mass (Da)51,009
- Last updated2004-10-11 v1
- Checksum7B1A2B828CDAE057
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 434-449 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX936398 EMBL· GenBank· DDBJ | CAH20818.1 EMBL· GenBank· DDBJ | Genomic DNA |