Q66662 · RIR2_EHV2
- ProteinRibonucleoside-diphosphate reductase small subunit
- GeneRIR2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids305 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
CHEBI:73316 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = CHEBI:57930 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 64 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 94 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 94 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 97 | Fe cation 1 (UniProtKB | ChEBI) | |||
Active site | 101 | ||||
Binding site | 157 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 191 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 194 | Fe cation 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell membrane | |
Cellular Component | membrane | |
Molecular Function | metal ion binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Biological Process | deoxyribonucleotide biosynthetic process | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonucleoside-diphosphate reductase small subunit
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Gammaherpesvirinae > Percavirus > Percavirus equidgamma2 > Equid gammaherpesvirus 2
- Virus hosts
Accessions
- Primary accessionQ66662
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 150-170 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000405980 | 1-305 | Ribonucleoside-diphosphate reductase small subunit | ||
Interaction
Subunit
Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.
Sequence
- Sequence statusComplete
- Length305
- Mass (Da)34,926
- Last updated1996-11-01 v1
- ChecksumF1204390ED97B026
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U20824 EMBL· GenBank· DDBJ | AAC13848.1 EMBL· GenBank· DDBJ | Genomic DNA |