Q66662 · RIR2_EHV2

Function

function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Features

Showing features for binding site, active site.

130520406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site64Fe cation 1 (UniProtKB | ChEBI)
Binding site94Fe cation 1 (UniProtKB | ChEBI)
Binding site94Fe cation 2 (UniProtKB | ChEBI)
Binding site97Fe cation 1 (UniProtKB | ChEBI)
Active site101
Binding site157Fe cation 2 (UniProtKB | ChEBI)
Binding site191Fe cation 2 (UniProtKB | ChEBI)
Binding site194Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenthost cell membrane
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process
Biological ProcessDNA replication

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase small subunit
  • EC number
  • Alternative names
    • Ribonucleotide reductase small subunit

Gene names

    • Name
      RIR2
    • Synonyms
      60

Organism names

Accessions

  • Primary accession
    Q66662

Proteomes

Subcellular Location

Host membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane150-170Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004059801-305Ribonucleoside-diphosphate reductase small subunit

Interaction

Subunit

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.

Structure

3D structure databases

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    34,926
  • Last updated
    1996-11-01 v1
  • Checksum
    F1204390ED97B026
MDFVKQFLYSCDHMGFLALTQETWQNRWFPSQISLTSDVACLQSLNPRDLEFYKFLFSFLAMAEKLVNFNIQALVADFHSHDLEHYYTEQEAMENIHGKVYANILNMFFKNNVGEMQKYAREIVGDEALAAKLHWLHGRVSEAKTRAEKVLVFLLIEGIFFISSFYSIATLRVRGLMNGVCMANDYISRDEWVHTRAAALLFNTLVPDEEKPSPEWIGALFREAVEVEYNFILAKGRGVSHVNVADINRFLEATADRILKSINVGPVYGTQPPPNCPLVYTGCLKNVNFFERESSDYTTAVDNDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U20824
EMBL· GenBank· DDBJ
AAC13848.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help