Q65951 · NP_ADECC

Function

function

Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Also plays a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Features

Showing features for site.

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TypeIDPosition(s)Description
Site23-24Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleolus
Cellular Componentviral capsid
Molecular FunctionDNA binding
Biological Processsymbiont entry into host cell
Biological Processviral penetration into host nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-histone-like nucleoprotein
  • Alternative names
    • Pre-core protein VII
      (pVII
      )
  • Cleaved into 1 chains

Gene names

    • Name
      L2

Organism names

Accessions

  • Primary accession
    Q65951

Subcellular Location

Histone-like nucleoprotein

Virion
Note: Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.

Pre-histone-like nucleoprotein

Host nucleus, host nucleolus

Keywords

PTM/Processing

Features

Showing features for initiator methionine, propeptide, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
PropeptidePRO_00004398382-23
ChainPRO_00004398372-132Pre-histone-like nucleoprotein
ChainPRO_000003658624-132Histone-like nucleoprotein

Post-translational modification

Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif124-132Nuclear localization signal

Sequence similarities

Belongs to the adenoviridae histone-like nucleoprotein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    132
  • Mass (Da)
    14,597
  • Last updated
    1997-11-01 v1
  • Checksum
    CA0AEA100136B7D3
MAILISPSNNTGWGLGTHKLFGGAKQKSDQHPVYVQAHYRAPWGGKGRRRPGRARGVPLDPKTEAEVVATIDEVARNGPPAARLVLEAARRVGAYNLRRARKLTPAGRAMAAMRARQMVNQAKRRKRRVRSK

Sequence caution

The sequence AAB05439.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U55001
EMBL· GenBank· DDBJ
AAB05439.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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