Q65951 · NP_ADECC
- ProteinPre-histone-like nucleoprotein
- GeneL2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids132 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Also plays a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.
Miscellaneous
All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 23-24 | Cleavage; by viral protease | ||||
Sequence: GA |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell | |
Cellular Component | host cell nucleolus | |
Cellular Component | viral capsid | |
Molecular Function | DNA binding | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral penetration into host nucleus |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePre-histone-like nucleoprotein
- Alternative names
- Cleaved into 1 chains
Gene names
Organism names
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Preplasmiviricota > Tectiliviricetes > Rowavirales > Adenoviridae > Mastadenovirus > Canine mastadenovirus A
- Virus hosts
Accessions
- Primary accessionQ65951
Subcellular Location
UniProt Annotation
GO Annotation
Histone-like nucleoprotein
Note: Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.
Pre-histone-like nucleoprotein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, propeptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Propeptide | PRO_0000439838 | 2-23 | ||||
Sequence: AILISPSNNTGWGLGTHKLFGG | ||||||
Chain | PRO_0000439837 | 2-132 | Pre-histone-like nucleoprotein | |||
Sequence: AILISPSNNTGWGLGTHKLFGGAKQKSDQHPVYVQAHYRAPWGGKGRRRPGRARGVPLDPKTEAEVVATIDEVARNGPPAARLVLEAARRVGAYNLRRARKLTPAGRAMAAMRARQMVNQAKRRKRRVRSK | ||||||
Chain | PRO_0000036586 | 24-132 | Histone-like nucleoprotein | |||
Sequence: AKQKSDQHPVYVQAHYRAPWGGKGRRRPGRARGVPLDPKTEAEVVATIDEVARNGPPAARLVLEAARRVGAYNLRRARKLTPAGRAMAAMRARQMVNQAKRRKRRVRSK |
Post-translational modification
Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.
Keywords
- PTM
Expression
Induction
Expressed in the late phase of the viral replicative cycle.
Keywords
- Developmental stage
Interaction
Subunit
Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 124-132 | Nuclear localization signal | ||||
Sequence: RRKRRVRSK |
Sequence similarities
Belongs to the adenoviridae histone-like nucleoprotein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length132
- Mass (Da)14,597
- Last updated1997-11-01 v1
- ChecksumCA0AEA100136B7D3