Q65949 · CAP3_ADECC

Function

function

Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Features

Showing features for site.

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TypeIDPosition(s)Description
Site548-549Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid, decoration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-hexon-linking protein IIIa
  • Alternative names
    • Capsid vertex-specific component IIIa
      (CVSC
      )
    • Protein IIIa
    • pIIIa
  • Cleaved into 1 chains

Gene names

    • ORF names
      L1

Organism names

Accessions

  • Primary accession
    Q65949

Subcellular Location

Virion
Host nucleus
Note: Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, propeptide.

TypeIDPosition(s)Description
ChainPRO_00004213901-548Hexon-linking protein IIIa
ChainPRO_00002218371-563Pre-hexon-linking protein IIIa
Modified residue235Phosphoserine; by host
Modified residue284Phosphothreonine; by host
Modified residue452Phosphoserine; by host
Modified residue456Phosphoserine; by host
Modified residue475Phosphoserine; by host
Modified residue486Phosphoserine; by host
PropeptidePRO_0000421389549-563

Post-translational modification

Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-117Peripentonal hexon-tethering domain
Region148-261Binding to hexon-linking protein
Region449-472Disordered
Compositional bias454-472Polar residues
Region522-543Disordered

Sequence similarities

Belongs to the adenoviridae hexon-linking protein IIIa family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    563
  • Mass (Da)
    63,283
  • Last updated
    1997-11-01 v1
  • Checksum
    4681E319AC6AFA63
MRKRRTLTAPSHFNSMSAALNPMKMAAMQSQPTVDDSWAASISRIMSLTAGDRHKFSSQPFANRLDAILEAVVPSRKDPTHEKVLTIVNALIENGAIRRDEGAGVYDALLHRVSKYNSINTQSNLERLAGDVREAVAQQVRIAAGNLGSLTALNSFLARLPANVERGQDNYTGFLSALKLLVSEVPNTEVYQSGPHYFLQSSRNGTQTVNLTNAFENLKPLWGVKAPTMERLSISALLTPNTRLLLLLVSPFTDSVSISRDSYLGYLLTLYREALGRNHLDERTLEEVTEVSKAMGNENINNLQATLNFLLTNRQKKIPKDYSLTPEEERIVRFIQQAVSLRMMQENLSPTEALDVTAANMEPSFYANNRDFINKLMDYFHRAAAIAPDYFLGAVMNPRWLPPEGFFTGVFDFPERDNYIWDGPDSSLDLTRQDAMRFLEEKFIDDDQRTESRSVSRVPTPASSRRSSVAMASDSLIRPMNNDKNSLREIEVLADKLARWKTYKRESEEARESLPVVVRPKKYSSAISSDESDDGMSKPDKFLKFEGSGNPFAHLRPKLGRCL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias454-472Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U55001
EMBL· GenBank· DDBJ
AAB05437.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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